Simwiary. \lMultiple forms of hydIrolytic enzymes Nvere deemonstrated in extracts of healthy tean leaves (Phla(scoluts vtulgaris L.) anld bean leaves infecte(d with the halo blight organism [Pseudoiiioiias phascolicola (Burkh.) Dowson] by polyacrylamide (lisc elecrophoresis. Bean leaves conitainiedl up to 4 acid l)hosphatase bands, 9 esterase banlds active towards a-niaphthyl acetate, alnd 7 es...

T cell receptors (TCR) containing Vβ20-1 have been implicated in a wide range of T cell mediated disease and allergic reactions, making it a target for understanding these. Mechanics of T cell receptors are largely unexplained by static structures available from x-ray crystallographic studies. A small number of molecular dynamic simulations have been conducted on TCR, however are currently lack...

Abstract Human leucocyte antigens (HLAs) display a repertoire of epitopic peptides on the cell surface for T recognition. Amino acid polymorphisms in peptide-binding groove different HLA allotypes result distinct antigenic repertoires, providing basis adaptive immunity to emerging pathogens at population level. receptors (TCRs) recognize pHLA through interactions with both peptide and heavy cha...

This paper highlights two cases of paediatric familial hyperlipidaemia (hypercholesterolaemia and hypertriglyceridaemia). The first case was an 11 year old Chinese boy, a "homozygous" (Type II) hypercholesterolaemic patient. He had extremely high blood cholesterol level (19.4 mmol/l), severe multiple xanthoma and abnormal resting electrocardiogram. He had repeated heart attacks and died at the ...

Recently, technology has become available to generate soluble T-cell receptors (sTCRs) that contain the antigen recognition part. In contrast to antibodies, sTCRs recognize intracellular in addition to extracellular epitopes, potentially increasing the number of applications as reagents for target detection and immunotherapy. Moreover, recent data show that they can be used for identification o...

HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the a3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide 'kinking' in the binding groove. Third, CD8 cytotoxic T lymphocytes that recognise HLA-A*6801-restricted antigens can tolerate substantial changes in the peptide sequ...

HLA class I incompatibilities still remain one of the main barriers for unrelated bone marrow transplantation (BMT); hence the molecular understanding of how to mismatch patients and donors and still have successful clinical outcomes will guide towards the future of unrelated BMT. One way to estimate the magnitude of polymorphisms within the PBR is to determine which peptides can be selected by...