Among retinal macular diseases, the juvenile recessive Stargardt disease and the age-related degenerative disease arise from carbonyl and oxidative stresses (COS). Both stresses originate from an accumulation of all-trans-retinal (atRAL) and are involved in bisretinoid formation by condensation of atRAL with phosphatidylethanolamine (carbonyl stress) in the photoreceptor and its transformation ...

The acylated phloroglucinol, hyperforin, the main active ingredient of St. John’s Wort, exerts antidepressant properties via indirect inhibition of serotonin reuptake by selectively activating the canonical transient receptor potential channel 6 (TRPC6). Hyperforin treatment can lead to drug–drug interactions due to potent activation of the nuclear receptor PXR (NR1I2), a key transcriptional re...

The naturally occurring acylated phloroglucinol derivative hyperforin was recently identified as the first specific canonical transient receptor potential-6 (TRPC6) activator. Hyperforin is the major antidepressant component of St. John's wort, which mediates its antidepressant-like properties via TRPC6 channel activation. However, its pharmacophore moiety for activating TRPC6 channels is unkno...

OBJECTIVE To determine the efficacy and tolerability of phloroglucinol, an antispasmodic agent in the treatment of Irritable Bowel Syndrome (IBS). METHODS It was an open label (quasi interventional) study. One hundred patients coming to the gastroenterology clinics of Aga Khan University Hospital with IBS as defined by the Rome II criteria were enrolled between February 2004 and September 200...

It has previously been ascertained] that the phloroglucinol or Jorissen test is among the most sensitive color tests for free formaldehyde. The advantages claimed for it are: (1) simplicity; (2) great sensitivity; (3) it reacts with free or liberated formaldehyde only, and does not itself liberate formaldehyde from such compounds as hexamethylenamine; (4) finally, with the phloroglucinol test t...

The acylated phloroglucinol, hyperforin, the main active ingredient of St. John's Wort, exerts antidepressant properties via indirect inhibition of serotonin reuptake by selectively activating the canonical transient receptor potential channel 6 (TRPC6). Hyperforin treatment can lead to drug-drug interactions due to potent activation of the nuclear receptor PXR (NR1I2), a key transcriptional re...

The first total synthesis of parameritannin A2 (1), a branched epicatechin (EC) tetramer is reported. “phloroglucinol trick” was used to circumvent two synthetic issues encountered when assembling four EC units, namely, the steric constraint and formation C4−C6 interflavan linkage. As substructure middle unit, phloroglucinol enabled single-step assembly units (top side) through A-type linkages....

1 SEPARATION AND CHARACTERIZATION OF PHLOROTANNINS FROM 1 BROWN ALGAE Cystoseira abies-marina BY COMPREHENSIVE TWO2 DIMENSIONAL LIQUID CHROMATOGRAPHY. 3 Lidia Montero, Miguel Herrero*, Elena Ibáñez, Alejandro Cifuentes 4 Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC), Nicolas 5 Cabrera 9, Campus de Cantoblanco, 28049 Madrid, Spain. 6 7 8 Abbreviations: D1, first dimens...

Three new meroterpenoids, guajavadials A-C (1-3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adduc...

3,4-dihydro-3-phenyl-2H-1,3-benzoxazines derived from phenol-, resorcinol-, and phloroglucinol give monomers with one, two, and three oxazine units at a single benzene ring, respectively. Aside from the synthesis and characterization of such multifunctional benzoxazines, reactivity and polymerization behavior is studied in dependence of the oxazine functionality. Monomer reactivities are direct...