نتایج جستجو برای: phosphatidylserines

تعداد نتایج: 3256  

Journal: :Analytical and bioanalytical chemistry 2011
Hye Kyeong Min Sangsoo Lim Bong Chul Chung Myeong Hee Moon

Qualitative and quantitative profiling of six different categories of urinary phospholipids (PLs) from patients with prostate cancer was performed to develop an analytical method for the discovery of candidate biomarkers by shotgun lipidomics method. Using nanoflow liquid chromatography-electrospray ionization-tandem mass spectrometry, we identified the molecular structures of a total of 70 PL ...

2015
Eyra Marien Michael Meister Thomas Muley Steffen Fieuws Sergio Bordel Rita Derua Jeffrey Spraggins Raf Van de Plas Jonas Dehairs Jens Wouters Muralidhararao Bagadi Hendrik Dienemann Michael Thomas Philipp A Schnabel Richard M Caprioli Etienne Waelkens Johannes V Swinnen

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the past decades has focused on identification of molecular changes in the genome, transcriptome, proteome, and more recently also the metabolome. Phospholipids, which nevertheless play a central role in cell functioning, remain poorly explor...

Journal: :Journal of lipid research 2010
Pavlina T Ivanova Stephen B Milne H Alex Brown

A large scale profiling and analysis of glycerophospholipid species in macrophages has facilitated the identification of several rare and atypical glycerophospholipid species. By using liquid chromatography tandem mass spectrometry and comparison of the elution and fragmentation properties of the rare lipids to synthetic standards, we were able to identify an array of ether-linked phosphatidyli...

Journal: :Journal of virology 2013
Vineela Chukkapalli Jingga Inlora Gabrielle C Todd Akira Ono

The matrix domain promotes plasma-membrane-specific binding of HIV-1 Gag through interaction with an acidic lipid phosphatidylinositol-(4,5)-bisphosphate. In in vitro systems, matrix-bound RNA suppresses Gag interactions with phosphatidylserine, an acidic lipid prevalent in various cytoplasmic membranes, thereby enhancing the lipid specificity of the matrix domain. Here we provide in vitro and ...

Journal: :Current Biology 2008
Donna L. Bratton Peter M. Henson

The recognition of phosphatidylserine (PS) on apoptotic cells within tissues drives both their engulfment and an accompanying anti-inflammatory and tissue restorative program. Insight into the recognition of this phospholipid signal by phagocytes is provided by papers describing three new, but completely different, PS receptors.

Journal: :The Journal of biological chemistry 1987
D Kreutter J Y Kim J R Goldenring H Rasmussen C Ukomadu R J DeLorenzo R K Yu

The activity of protein kinase C (Ca2+/phospholipid-dependent enzyme) in the presence of phosphatidylserine and its physiological regulator, diacylglycerol, could be suppressed by a mixture of brain gangliosides. Half-maximal inhibition was observed at 30 microM and was nearly complete at 100 microM. Inhibition was observed at all concentrations of Ca2+ between 10(-8) and 10(-4) M. Inhibition o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Sean T H Liu Ronit Sharon-Friling Pavlina Ivanova Stephen B Milne David S Myers Joshua D Rabinowitz H Alex Brown Thomas Shenk

Human cytomegalovirus induces and requires fatty acid synthesis. This suggests an essential role for lipidome remodeling in viral replication. We used mass spectrometry to quantify glycerophospholipids in mock-infected and virus-infected fibroblasts, as well as in virions. Although the lipid composition of mock-infected and virus-infected fibroblasts was similar, virions were markedly different...

Journal: :Biochimica et biophysica acta 2008
Jane M Deeley Todd W Mitchell Xiaojia Wei John Korth Jessica R Nealon Stephen J Blanksby Roger J W Truscott

Electrospray ionisation tandem mass spectrometry has allowed the unambiguous identification and quantification of individual lens phospholipids in human and six animal models. Using this approach ca. 100 unique phospholipids have been characterised. Parallel analysis of the same lens extracts by a novel direct-insertion electron-ionization technique found the cholesterol content of human lenses...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
László G Puskás Klára Kitajka Csaba Nyakas Gwendolyn Barcelo-Coblijn Tibor Farkas

Reduced brain levels of long chain polyunsaturated fatty acids [arachidonic acid and docosahexanoic acid (DHA)] are observed in elderly subjects and patients with Alzheimer's disease. To determine the effects of n-3 fatty acids on aged rat brain, 2-year-old rats were fed fish oil (27% DHA content) for 1 month, and gene expression analysis and fatty acid and molecular species composition of the ...

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