Our major aim was to systematically study the effectiveness of phosphodiesterase type 5 inhibitors in treating chronic prostatitis stage III and performed meta-analysis evaluate changes occurred posttreatment scores National Institutes Health symptom index, international index erectile function prostate score. This conducted according preferred reporting items for systematic reviews meta-analys...

PURPOSE To characterize cyclic nucleotide phosphodiesterase isozyme activities in human trabecular meshwork cells and primary cultures of porcine trabecular meshwork cells. METHODS Radioimmunoassay of acetylated acid extracts was used to determine changes in cyclic adenosine monophosphate (cAMP) and cyclic quanosine monophosphate (cGMP) in human trabecular meshwork cells treated with phosphod...

Alzheimer’s disease is a memory-related neurodegenerative condition leading to cognitive impairment. Cholinergic deficit, together with other underlying mechanisms, leads the onset and progression of disease. Consequently, acetylcholinesterase inhibitors are used for symptomatic treatment dementia, even if limited efficacy observed. More recently, some specific phosphodiesterase isoforms emerge...