A library of synthetic full-length Max transcription factor variants with distinct modifications was prepared to investigate the impact Ser phosphorylation, as reported by Ariel Afek, Muhammad Jbara et al. in their Research Article (e202310913). Comprehensive DNA binding analysis and high-throughput screening revealed that phosphorylation pattern plays a crucial role DNA-binding activity but do...

Adenosine triphosphate (ATP) is known as an energy source and generated by mitochondria which the powerhouse of cell. The ATP supplies through disassociation phosphate group cellular enzymes. extracellular in environment acts a signaling molecule can act anti-inflammatory molecule, promote cancer progression, also pro-inflammatory molecule. degradation major disadvantage ectonucleotidases that ...

• The molecular chaperone CCT has functions in addition to protein folding. oncogenic transcription factor STAT3 binds oligomer. is not an obligate folding substrate of CCT. Reduction levels leads enhanced phosphorylation MCF7 cells. Sequestration by may provide a means regulate phosphorylation. Chaperonin Containing Tailless complex polypeptide 1 (CCT) essential required for the abundant prote...

Exchange Proteins directly Activated by cAMP (EPACs) belong to a family of RAP guanine nucleotide exchange factors (RAPGEF). EPAC1/2 (RAPGEF3/4) activate RAP1 and the alternative signaling pathway. We previously showed that differential growth response primary metastatic melanoma cells is mediated EPAC. However, mechanisms responsible for this EPAC are not understood. In study, we show pharmaco...

Background: The purpose of this study was to examine the impact of Insulin (INS) on human sperm function, in light of a recent proteomic analysis indicating that these cells express the INS receptor (INSR). Materials and Methods: We used Western blot and Immunocytochemical analyses. Results: Immunocytochemical analyses confirmed the presence of INSR in human spermatozoa and localized this recep...

Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. loss of protein associates tumor metastasis and poor survival GC patients. During progression, an aberrantly elevated miR-20a-5p expression has been found, which induces phosphorylation, t...

recognition of the molecular mechanisms of camp action against dna damage-induced apoptosis can be useful to improve the efficacy of dna damaging therapeutic agents. considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-trea...

objective(s):  the role of the apoptosis repressor with caspase recruitment domain (arc) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of endothelin-1 induced cardiac hypertrophy remains unknown. the present study discusses the inhibitory role of arc against endothelin–induced hypertrophy. results:in present study endothelin treated card...

background: dihydropyrimidinase related proteins (drps) have known homologous to the collapsing response mediator proteins (crmps). the drp gene family has comprised four members, drp 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding. methods: the protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated ...