Photodynamic Therapy of Tumors In article number 2205440, Zhiyang Liu, Quan Li, and co-workers exploit the hypoxic properties solid tumors to construct a hypoxia-responsive photosensitizer. When non-fluorescent photosensitizer enters tumors, it is reduced by overexpressed azoreductase generate fluorescent with aggregation-induced emission property, which can realize fluorescence-activatable ima...

Background Photodynamic therapy (PDT) is a promising new cancer treatment strategy which inactivates tumor cells by simultaneoulsy using light and a photosensitizer. The similarity between tumors and newly implanted embryos is notable. Extrauterine pregnancy (EUP) does not have a definite treatment and previous therapeutic options (medical and surgical) have not been effective or suitable. Ther...

PURPOSE The ATP-binding cassette protein ABCG2 (breast cancer resistance protein) effluxes some of the photosensitizers used in photodynamic therapy (PDT) and, thus, may confer resistance to this treatment modality. Tyrosine kinase inhibitors (TKI) can block the function of ABCG2. Therefore, we tested the effects of the TKI imatinib mesylate (Gleevec) on photosensitizer accumulation and in vitr...

Photodynamic therapy is a complex treatment for neoplastic diseases that uses the light-harvesting properties of a photosensitizer. The treatment depends on the amount of photosensitizer in the tissue and on the amount of light that is focused on the targeted area. We use a pharmacokinetic model to represent a photosensitizer’s movement through the anatomy and design treatments with a linear pr...

OBJECTIVES The purpose of this study was to evaluate the clinical plaque disclosing agent erythrosine as a photosensitizer in the photodynamic killing of the oral bacterium Streptococcus mutans grown as a biofilm. METHODS S. mutans biofilms of 200 microm thickness were grown in a constant-depth film fermenter. In addition to determining localization of the photosensitizer within biofilms usin...

Photodynamic therapy is a relatively new and potentially selective experimental approach to the treatment of malignant neoplasms. Its inherent dual selectivity is reinforced by the use of photosensitizer-monoclonal antibody conjugates. The goal of this study was to evaluate the phototoxicity and selectivity of an immunoconjugate (IC) synthesized from a chlorin derivative chlorin e6-monoethylene...

A combination of noble-metal free components, a water soluble porphyrin photosensitizer zinc meso-tetrakis(1-methylpyridinium-4-yl)porphyrin chloride [ZnTMPyP(4+)]Cl4 (1) with cobaloxime complex [Co(III)(dmgH)2(py)Cl] (2) as a catalyst, creates an efficient system for photochemical hydrogen production acting under visible light with 280 TONs. This is the first example of a water soluble porphyr...

A cyclodextrin dimer has been synthesized with two beta-cyclodextrins linked by a flexible chain containing a carbon-carbon double bond. This dimer binds and solubilizes a phthalocyanine-based photosensitizer that generates singlet oxygen on irradiation. When the complex is irradiated, the singlet oxygen cleaves the carbon-carbon link, and the cyclodextrins are released, liberating the photosen...

The photodynamic effects of sulphonated zinc and aluminum phthalocyanine derivatives as well as phosphonated aluminum phthalOcyanine on the firing of isolated crayfish mechanoreceptor neurons were studied. After 30 min staining neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm2) and changes in neuron firing frequency were recorded. Neuron firing was found to be very sensitive to phot...

While Photofrin, the photosensitizer currently in clinical use for photodynamic therapy (PDT) of tumours, has been shown to be both efficacious and safe in the treatment of a variety of human cancers, its chemical heterogeneity and low absorbance in the phototherapeutically useful wavelength range (600-850 nm) make the development of new photosensitizers with improved characteristics desirable....