OBJECTIVE The PI-3 kinase-Akt pathway plays a role in cartilage anabolic as well as catabolic processes in response to activation by insulin-like growth factor-1 (IGF-1) and the pro-inflammatory cytokines interleukin-1β (IL-1β) and oncostatin M (OSM). The goal of this study was to determine how PI-3 kinase-Akt signaling regulates these seemingly opposing functions. DESIGN Monolayer cultures o...

A number of phosphate (Pi) starvationor mycorrhiza-regulated Pi transporters belonging to the Pht1 family have been functionally characterized in several plant species, whereas functions of the Pi transporters that are not regulated by changes in Pi supply are lacking. In this study, we show that rice (Oryza sativa) Pht1;1 (OsPT1), one of the 13 Pht1 Pi transporters in rice, was expressed abund...

OBJECTIVE To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE). METHODS Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected control...

We investigated memory performance and cardiovascular activity in 13 primary insomniacs (PI) compared to 13 good sleepers (GS). Cardiovascular and hemodynamic measures, including heart rate, pre-ejection period, and blood pressure, were continuously recorded at rest and during two memory tasks. PI showed working memory impairment under high cognitive load, but performed as well as GS in an easy...

A number of phosphate (Pi) starvation- or mycorrhiza-regulated Pi transporters belonging to the Pht1 family have been functionally characterized in several plant species, whereas functions of the Pi transporters that are not regulated by changes in Pi supply are lacking. In this study, we show that rice (Oryza sativa) Pht1;1 (OsPT1), one of the 13 Pht1 Pi transporters in rice, was expressed abu...

The $\it{\Xi_{cc}^{++}\to \Xi_{c}^{'+}\pi^{+}}$ decay is observed using proton-proton collisions collected by the LHCb experiment at a centre-of-mass energy of $13\mathrm{\,Te\kern -0.1em V}$, corresponding to an integrated luminosity $5.4\,\mathrm{fb}^{-1}$. reconstructed partially, where photon from $\it{\Xi_{c}^{'+} \to \Xi_{c}^{+}\gamma}$ not and $pK^-\pi^+$ final state $\it{\Xi_{c}^{+}}$ b...

Discurso-programa del Sr. Presidente Ejecutivo (Francisco Pi y Margall) en las Cortes Constituyentes de la República española el 13 junio 1873 (Diario Sesiones, número 13, pp. 137-140). (Se acompaña comentario «Eclosión libertades conflictos implacables: Gobierno Margall encrucijadas 1873», Juan Sisinio Pérez-Garzón).

The molecular structures of two salicylaldehyde thiosemicarbazone derivatives, namely salicylaldehyde 4-phenylthiosemicarbazone, C(14)H(13)N(3)OS, (I), and 4-methoxysalicylaldehyde 4-phenylthiosemicarbazone, C(15)H(15)N(3)O(2)S, (II), both of potential pharmacological interest, are found in the keto (thione) tautomeric form. The first compound represents a second triclinic polymorph of composit...

OBJECTIVES Uterine artery Doppler flow studies during the 11th and 14th week of pregnancy are important in the prediction of preeclampsia and intrauterine growth restriction in pregnant women as well as in the prevention thereof. METHODS Our study on Doppler flow indices of the uterine arteries involved 168 patients examined in our clinic, with pregnancies ranging from 11 weeks + 0 days to 13...