Placental growth factor (PlGF) is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides its well known capacity to potentiate the angiogenic action of VEGF, PlGF also participates in inflammatory processes by attracting and activating monocytes; it plays therefore more specifically a role in pathological conditions. PIGF and its two receptors, VEGFR-...

Trophoblast cell dysfunction is involved in many disorders during pregnancy such as preeclampsia and intrauterine growth restriction. Few treatments exist, however, that target improving trophoblast cell function. Human umbilical cord mesenchymal stem cells (hUCMSCs) are capable of self-renewing, can undergo multilineage differentiation, and have homing abilities; in addition, they have immunom...

Background Rheumatoid arthritis (RA) has been associated with increased angiogenesis and the production of angiogenic factors. Targeted therapies may attenuate molecule production. Objectives We wished to determine how Janus kinase (JAK) inhibitor tofacitinib influences various mediators including growth factors, cytokines, chemokines, adhesion molecules others. correlated these biomarkers ultr...

Twin pregnancies demonstrate a 2–3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well imminent deliveries due complications. The primary objective this systematic review was summarise available data on levels sFLT1, PlGF their ratios in twin investigate ass...

BACKGROUND Sickle cell disease has a worldwide distribution. Vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease. Thrombospondin (TSP1) and Placenta growth factor (PlGF) have been reported to be involved in sickle cell diseases (SCD). OBJECTIVE The aim of this study was to assess the clinical significance of Thrombospondin and Placenta growth factor profi...