Merle is a pattern of coloring observed in the coat of the domestic dog and is characterized by patches of diluted pigment. This trait is inherited in an autosomal, incompletely dominant fashion. Dogs heterozygous or homozygous for the merle locus exhibit a wide range of auditory and ophthalmologic abnormalities, which are similar to those observed for the human auditory-pigmentation disorder W...

BACKGROUND Familial hemophagocytic lymphohistiocytosis (FHL) is a rare and often fatal disorder characterized by defective cellular cytotoxicity and hyperinflammation, and the only cure known to date is hematopoietic stem cell transplantation. Mutations in RAB27A, LYST, and AP3B1 give rise to FHL associated with oculocutaneous albinism, and patients with FHL are usually only screened for mutati...

The patient was a 7-year-old child of gypsy origin, with no relevant personal history, who presented with progressively developing, asymptomatic, hyperpigmented lesions, first observed 11 months earlier. The lesions had started to appear on the upper part of the trunk and had shown a centrifugal progression, becoming generalized over the course of a few months. No triggering event was identifie...

Background: Melanin pigmentation of the gingiva occurs in allethnicities. Excessive pigmentation is an esthetic concern thathas increased awareness about depigmentation procedures. Thepurpose of the present study was to correlate the skin color andgender with the intensity and distribution of gingival melaninpigmentation in a group of South Indians for treatment strategies.Method: Two hundred m...

(4) Pigmentation of Polymita picta (5) Pigmentation of Cepaea nemoralis (6) Conclusion . . . . . . . . (2) General characters of helicid pigmentation . . (3) Colour associations and interchangeability of pigments . . . . . . . . V. Summary . . . . . . . . . VI. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PAGE 285 286 288 288 289 289 292 2...

X-linked reticulate pigmentation disorder with systemic manifestations (XLPDR) is an extremely rare genodermatosis with recessive X-linked inheritance but unknown molecular basis. In males, cutaneous involvement is characterized by reticulate hyperpigmentation of the skin that is associated with a typical facies and severe systemic involvement. In the carrier females, manifestations are apparen...

Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ...

Sir, Dowling-Degos disease (DDD) is a rare disorder characterized by acquired pigmented macules and papules in a reticulate pattern, particularly affecting the flexural areas and other major skin folds (1, 2). A female patient presented with dotted and reticulate pigmentation of the axilla, and was diagnosed as DDD both clinically and histopathologically. However, the asymmetrical distribution ...

introduction: melanin pigmentation in the oral mucosa occurs as a result of several reasons one of which is smoking. cigarette smoke induces numerous side effects in the people who do not smoke, but are in the same environment. the aim of this study was to evaluate the role of parental smoking on pigmentation of their children's oral mucosa. materials and methods: this study was carried out as ...

statement of the problem: melanin pigmentation of the gingiva is a crucial esthetic problem. a variety of methods have been used for gingival depigmentation. purpose: the purpose of this study was to compare the results of two treatment modalities: scalpel technique and cryotherapy with liquid nitrogen in treatment of gingival pigmentation. materials and method: twenty patients with chief compl...