Objective: To investigate newborns’ sizes associated with abruptio placentae (AP) and to assess the association of a history of pregnancy induced hypertension (PIH) and low birth weight with the occurrence of AP and vice versa. Design: A cohort study based on the Medical Birth Registry of Norway. Results: AP in the first birth was associated with higher rates of AP, small for gestational age (S...

OBJECTIVE To investigate whether pregnancy-induced hypertension (PIH) may increase oxidative stress in women with PIH, and to explore the mechanisms by which PIH may increase oxidative stress and potential free radical damage. METHODS Seventy women with PIH and seventy women with uncomplicated normotensive pregnancy (UNP) whose age, nutritional conditions, levels of hemoglobin and albumin wer...

OBJECTIVES Our earlier studies have highlighted that an altered one carbon metabolism (vitamin B12, folic acid, and docosahexaenoic acid) is associated with preeclampsia. Preeclampsia is also known to be associated with oxidative stress and inflammation. The current study examines whether maternal folic acid, vitamin B12 and omega-3 fatty acid supplementation given either individually or in com...

Reports indicate that pregnancy induced hypertension (PIH) is known to have long term adverse effects both in the mother and offspring. At present, the pathogenesis of PIH is incompletely understood. Recent studies on microRNA (miRNA) offer the possibility for developing a new class of molecular markers for diagnosis of PIH. However, the function of miRNAs in the development of PIH remains unkn...

Previous workers have emphasized the possibility that pregnancy-induced hypertension (PIH) is associated with a change of sexual partner. It is noted here that any such association is far weaker than that between PIH and fecundability (the probability of conceiving in a month at risk). This latter association is so strong as to suggest its closeness to a true cause. Of the determinants of fecun...

The mean heart weight as a measure of arterial hypertension of patients who died from spontaneous intracerebral hemorrhage (primary intracerebral hemorrhage or PIH) was compared with that of controls from the same autopsy population. All patients with valvular or congenital heart disease or disease processes associated with myocardial infiltration were excluded. In 206 cases of PIH, hypertensio...

OBJECTIVE This study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence. METHODS Double-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the perip...

To investigate the activation of particulate guanylate cyclase in pregnant women with pregnancy-induced hypertension (PIH), plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanosine 3',5'-cyclic phosphate (cGMP) were measured by radioimmunoassays specific to each substance. Ten normal nonpregnant women, and 30 normal pregnant women, 17 pregnant women with...

We assessed whether a pregnant woman who was born small for gestational age has increased risk of pregnancy-induced hypertension (PIH), and whether the same applies to a pregnant partner of a man who was born small for gestational age. We linked generational data from the medical birth registry of Norway (1967-2005). Female and male newborns were identified as parents with 197,716 and 131,959 f...

Objective. In this study, we have assessed sympathovagal imbalance (SVI) by spectral analysis of heart rate variability (HRV) that contributes to the genesis of early-onset PIH. Methods. Body mass index (BMI), basal heart rate (BHR), blood pressure (BP) and HRV indices such as LFnu, HFnu, LF-HF ratio, mean RR, SDNN and RMSSD were assessed in normal pregnant women (Control group) and pregnant wo...