PINCH-1 is a LIM-only domain protein that forms a ternary complex with integrin-linked kinase (ILK) and parvin (to form the IPP complex) downstream of integrins. Here, we demonstrate that PINCH-1 (also known as Lims1) gene ablation in the epidermis of mice caused epidermal detachment from the basement membrane, epidermal hyperthickening and progressive hair loss. PINCH-1-deficient keratinocytes...

Reconstructive hand surgeries restore key pinch to individuals with pinch force deficits caused by tetraplegia. Data that define the magnitudes of force necessary to complete functional key pinch tasks are limited. This study aims to establish target pinch forces for completing selected tasks that represent a range of useful functional activities. A robot arm instrumented with a force sensor co...

We analyze ill-defined pinch singularities characteristic of out of equilibrium thermal field theories. We identify two mechanisms that eliminate pinching even at the single selfenergy insertion approximation to the propagator: the first is based on the vanishing of phase space at the singular point (threshold effect). It is effective in QED with a massive electron and a massless photon. In mas...

BACKGROUND Several clinical measures of sensory and motor function are used alongside patient-rated questionnaires to assess outcomes of carpal tunnel decompression. However there is a lack of evidence regarding which clinical tests are most responsive to clinically important change over time. METHODS In a prospective cohort study 63 patients undergoing carpal tunnel decompression were assess...

PURPOSE Surgical transfers of muscles are used to restore lateral pinch in tetraplegia; however, outcomes are variable. The purpose of this study was to compare activation of the brachioradialis (Br) after transfer to the flexor pollicis longus during maximum effort in its primary function (elbow flexion) with maximum effort in its postoperative function (lateral pinch) and to record Br activat...

A physical model of turbulent equipartition (TEP) of plasma angular momentum is developed. We show that using a simple, model insensitive ansatz of conservation of total angular momentum, a TEP pinch of angular momentum can be obtained. We note that this term corresponds to a part of the pinch velocity previously calculated using quasilinear gyrokinetic theory. We observe that the nondiffusive ...