Background: Glypican-3 (GPC3) is expressed in most of hepatocellular carcinoma (HCC) and GPC3 immunohistochemical staining widely used the clinical setting, but it has not been recommended as a blood biomarker, mainly due to its heterogeneous nature lack established assay system. Here, we developed evaluated basic performance fully automated immunoassay kits which detect full-length or N-termin...

The freshwater isopod crustacean Asellus aquaticus has recently been developed as an emerging invertebrate cave model for studying evolutionary and developmental biology. Mostly morphological and genetic differences between cave and surface A. aquaticus populations have been described up to now, while scarce data are available on other aspects, including physiology. The purpose of this study wa...

Abstract Background and Aims Kidney transplantation is the best treatment for end-stage renal disease (ESRD). Osteoporosis a common health problem in kidney transplant recipients. It known that risk of bone fracture increases by 30% first 3 years after Vitamin K cofactor involved activation osteocalcin. This protein plays role mineralization. Currently, vitamin cannot be measured directly from ...

Background. The purpose of the work is to study blood content biologically active substances — peptides and hormones that can affect pressure development hypertension, depending on gender disease course in adolescents aged 17 years by comparing them with healthy individuals. Materials methods. There were examined 87 (37 boys 50 girls) who divided into 4 main groups stable labile hypertension 2 ...

BACKGROUND Matrix Gla protein (MGP) is an extrahepatic protein that is dependent on glutamate carboxylation, a vitamin K-dependent process. Its dysfunctional form, desphospho-uncarboxylated-MGP, has been associated with increased arterial calcification and stiffness. The aim of this study was to measure the degree of postoperative carboxylation of MGP and two other Gla proteins in patients sche...

PURPOSE The risk of hepatocellular carcinoma (HCC) recurrence must be considered ahead of surgery. This study was undertaken to identify pre-operative risk factors for early intrahepatic recurrence of HCC after curative resection in a large-scale. MATERIALS AND METHODS We retrospectively reviewed the preoperative three-phase multi-detector CT (MDCT) and laboratory data for 240 HCC patients wh...