نتایج جستجو برای: placebo 1
تعداد نتایج: 2797334 فیلتر نتایج به سال:
purpose: in this study the effect of iron supplmentation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl was investigated. material and methods: in this experimental clincal study, the effect of iron supplementation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl and ferritin> 14.3 μg/l during the 13th- 18th pregnancy week was studied. eighty seven women havin...
People who become hyperthermic during exercise display large increases in heart rate (HR) and reductions in stroke volume (SV). It is not clear if the reduction in SV is due primarily to hyperthermia or if it is a secondary effect of an elevation in HR reducing ventricular filling. In the present study, the upward drift of HR during prolonged exercise was prevented by a very small dose of the β...
Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...
In terms of advancement of life to meet the challenges new method for neuropsychopharmacological research are continually developing to ensure superior safety, accuracy, efficacy, precision etc. In this experiment, we suggested and validated two neuropsychopharmacological testing methods, these are Numeral Finding (NF) and Typo Revealing (TR) tests for the determination of attention in healthy ...
BACKGROUND The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated alirocumab 150 mg Q4W in patients with inadequately controlled hypercholesterolemia and not on statin (majority with statin-associated muscle symptoms), rece...
BACKGROUND Preventive medication is indicated for many migraine patients, but is used in relatively few. The aim of the present study was to evaluate the efficacy of acetyl-l-carnitine as a prophylactic drug in migraine patients. METHODS A single-center, randomized, triple-blind, placebo-controlled, crossover study was carried out. Men and women, age 18-65 years, with episodic migraine but ot...
Efficacyand safety of a new herbal cream containing aqueous extracts of Azadirachta indica, Curcuma longa, Pongamia glabra, Glycyrrihiza glabra and Santallum album were evaluated in amulticentric, randomized, double-blind, placebo-controlled study. With active drug treatment, there was significant improvement in various signs like redness, oedema and symptoms like itching, burning, discharge an...
Background: Efgartigimod is a human IgG1 antibody Fc-fragment that reduces IgG levels through FcRn blockade. A key efficacy indicator in the treatment of autoantibody-mediated generalized myasthenia gravis (gMG) improvement MG-ADL score. Methods: The ADAPT phase 3 trial evaluated safety and efgartigimod patients with gMG, including reaching maintaining minimal symptom expression (MSE; defined a...
background: premenstrual syndrome (pms) is a condition characterized by a number of behavioral, psychological and physical symptoms recurring cyclically during the luteal phase of the menstrual cycle. the uncertainty in the pathogenesis of pms has led to many treatment protocols being suggested as possible therapies. the present study was carried out to compare the effects of echinophora-platyl...
objective: to evaluate the safety and efficacy of isosorbide mononitrate (imn) as a cervical ripening agent prior to induction of labour in term pregnant women. materials and methods: a randomized placebo-controlled study was conducted on 100 term singleton pregnancies planned for induction of labour. the participants were randomly assigned to two groups. one group received 40 mg imn and the ot...
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