OBJECTIVE The purpose of this study was to determine the ex vivo human placental transfer of rifampin and rifabutin. METHODS Seven placentas from uncomplicated term vaginal or cesarean deliveries were studied utilizing the ex vivo single cotyledon perfusion system. Antipyrine was used for the reference compound in the determination of the clearance indices of rifampin and rifabutin. RESULTS...

OBJECTIVE The purpose of this study was to determine the ex vivo human placental transfer of trovafloxacin from the maternal circulation to the fetal circulation. METHODS Six placentas from uncomplicated, term, vaginal or cesarean deliveries were studied using the ex vivo isolated cotyledon perfusion chamber; 14C-antipyrine was used as a reference compound to determine the clearance index (CI...

Laurent Mandelbrot, Dominique Duro, Emilie Belissa, Gilles Peytavin Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Hôpitaux Universitaires Paris-Nord Val de Seine, Colombes, France; Université Paris-Diderot, Université Sorbonne Paris-Cité, DHU Risks in Pregnancy, Paris, France; INSERM U1018, Kremlin-Bicêtre, France; Assistance Publique-Hôpitaux...