نتایج جستجو برای: plasminogen activator

تعداد نتایج: 52174  

Journal: :The Journal of biological chemistry 1965
C M Ling L Summaria K C Robbins

It has been shown that the activation of bovine plasminogen by streptokinase plus a trace amount of human globulin involves a two-stage activation process (1, 2). Ablondi and Hagan (3) proposed that the proactivator of bovine plasminogen was identical with human plasminogen, which became activator by forming complexes with streptokinase. Kline and Fishman (4) using a lysine methyl ester assay d...

Journal: :Stroke 2010
Xiang Fan Zhanyang Yu Jianxiang Liu Ning Liu Katherine A Hajjar Karen L Furie Eng H Lo Xiaoying Wang

Hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and the short treatment time window comprise major challenges for thrombolytic therapy. Improving tissue plasminogen activator therapy has become one of the highest priorities in the stroke field. Recent efforts have been aimed at identifying new strategies that might enhance the thrombolytic efficacy of tissue plasminogen activ...

2014
Kristina Svennerholm Niklas Bergh Pia Larsson Sverker Jern Göran Johansson Björn Biber Michael Haney

BACKGROUND The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control. OBJECTIVES The study aimed to test if in vivo pharmacological intervention by valproic acid treatment would lead to increase in tissue plasminogen activator release capacity. METHODS In an anaesthetized pig model, a controlle...

Journal: :The Journal of clinical investigation 1982
C Korninger O Matsuo R Suy J M Stassen D Collen

Extrinsic (tissue-type) plasminogen activator (plasminogen activator) was isolated either as a single-chain or as a two-chain molecule from the culture medium of a human melanoma cell line. The thrombolytic activity of both molecular forms of activator was investigated in beagle dogs with an experimental femoral vein thrombosis and compared with that of urokinase. The 125I-fibrinogen-labeled th...

Journal: :Gut 1997
D M Scott-Coombes S A Whawell E G Havranek J N Thompson

AIMS To investigate the fibrinolytic activity of normal and calculous human bile. METHODS Fibrinolytic properties of the biliary tract were studied in patients with gall bladder stones (n = 7) compared with acalculous gall bladders (n = 8). RESULTS Bile plasminogen activating activity was detected in a wide range in both groups (calculous bile median 0.35 IU/ml; range: 0.06-6.59, versus nor...

Journal: :Investigative ophthalmology & visual science 2000
A Csutak J Tözsér L Békési Z Hassan A Berta D M Silver

PURPOSE To quantify changes of plasminogen activator activity in tear fluid during corneal re-epithelialization after excimer laser photorefractive keratectomy (PRK). METHODS Tear samples were collected with glass capillaries from 77 eyes of 42 patients immediately before and immediately after PRK treatment and on postoperative days 3 and 5. In 20 patients, the contralateral eye was similarly...

Journal: :Thorax 1988
B W Robinson

Increased production of the serum protease plasminogen activator is associated with tissue damage. The in vitro production of plasminogen activator by alveolar macrophages obtained by bronchoalveolar lavage was studied in 22 normal subjects and 28 patients with interstitial lung disease to determine whether plasminogen activator is produced by normal alveolar macrophages and whether this is inc...

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