background: cerebral malaria (cm) is one of the major causes of death in african populations infected with plasmodium falciparum. only 1% of infected subjects develop cm. the reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...

BACKGROUND Malaria is well known for its fatalities worldwide, Plasmodium vivax and the Plasmodium falciparum are the two important species of malaria reported from Pakistan and creating lots of morbidities across the country. METHOD Study was conducted to determine the Surveillance of malaria in South Punjab by microscopy and Polymerase chain reaction (PCR). RESULT samples out of 100 patie...

BACKGROUND Malaria retinopathy has been proposed as marker of "true" cerebral malaria (CM), ie, coma due to Plasmodium falciparum vs coma due to other causes, with incidental P falciparum parasitemia. Plasma P falciparum histidine-rich protein-2 (PfHRP2) concentrations distinguish retinopathy-positive (RP) from retinopathy-negative (RN) CM but have not been compared between RN CM and other form...

Recent molecular exploration of the Plasmodium species circulating in great apes in Africa has revealed the existence of a large and previously unknown diversity of Plasmodium. For instance, gorillas were found to be infected by parasites closely related to Plasmodium falciparum, suggesting that the human malignant malaria agent may have arisen after a transfer from gorillas. Although this scen...

Plasmodium falciparum malaria remains a disease of significant public health impact today. With the risk emerging artemisinin resistance stalling control efforts, need to deepen our understanding parasite's biology is dire. Extracellular vesicles (EVs) are vital P. and play role in pathogenesis malaria. Recent studies have also shown that EVs may development falciparum. Here, we highlight evide...

Mixed malaria infections, Plasmodium falciparum and P. vivax, are suspected to occur at a greater frequency than is detected by conventional light microscopy. In order to determine the year round pattern of transmission and the frequency of mixed infections in malaria endemic area, we carried out a prospective comparison of diagnosis by conventional light microscopy and nested PCR in Chahbahar ...

The combination of anemia in malarial infestations ranges from nutritional deficiency to marrow suppression. An immune hemolytic anemia in Plasmodium falciparum malaria is also a part of this wide-ranging spectrum. But the co-existence of cold agglutinins in a Plasmodium falciparum malaria has only sporadically been reported in literature. We present a case of a patient with falciparum malaria ...

Malaria is transmitted to humans by mosquitoes of the genus Anopheles. Malaria is known to be caused by four plasmodia species, namely Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, with P. falciparum being the most lethal. There are increasing reports of a fifth human-infecting species, Plasmodium knowlesi, which has been described in south-east Asian countr...

background& objectives: inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. it is a protozoan disease transmitted by the bite of infected female anopheles mosquito. malaria has long featured prominently in the grey area between parasitology and hematology. this study has been performed to evaluate ...