Bone-seeking (osteotropic) drug delivery systems (ODDS) represent an interesting solution for targeting different types of drugs to the bones. In particular, anticancer and antibacterial agents could take advantage of such therapeutic strategy. We have recently developed an innovative approach to this aim: a new osteotropic biomaterial was prepared, based on the conjugation of a poly(lactide-co...

In this study, multifunctional theranostic agents for photoacoustic (PA), ultrasound (US), fluorescent imaging, and for therapeutic drug delivery were developed and tested. These agents consisted of a shell made from a biodegradable Poly(lactide-co-glycolic acid) (PLGA) polymer, loaded with perfluorohexane (PFH) liquid and gold nanoparticles (GNPs) in the core, and lipophilic carbocyanines fluo...

Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance, the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly(lactic-co-glycolic acid) (PLGA) are...

Abstract Background In an attempt to prove biological activity enhancement upon escalating the cellular uptake response through ligand and carrier-based via nanoframework, gallic acid was chosen be formulated into PLGA-based polymeric nanoparticles with iron oxide as theranostic agent. Results The pre-formulation studies like FTIR, DSC, XRD, TGA were carried out, which implies good compatibilit...

In this work, we introduce, for the first time, novel hybrid microneedle patches with implantable poly(lactic- co -glycolic acid) (PLGA) tips aligned hydrogel-forming bases (HFMB) using a dissolvable material. A model dye, Nile red, and an antifungal drug, amphotericin B, were loaded into PLGA in controlled manner by multiple castings. Three different types of pre-formed including conventional ...

This paper focuses on novel approaches in the field of nanotechnology-based carriers utilizing ultrasound stimuli as a means to spatially target gene delivery in vivo, using nanoparticles made with either poly(lactic-co-glycolic acid) (PLGA) or other polymers. We specifically discuss the potential for gene delivery by particles that are echogenic (amenable to destruction by ultrasound) composed...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Abstract: Aim: This article describes how biodegradable polymers and their drug delivery mechanisms can be used to monitor maintain local or targeted distribution. Polylactic-co-glycol acid has been one of the most appealing polymeric candidates for creating release tissue engineering products over last couple decades. PLGA a variety purposes due its biodegradability biocompatibility. Materials...

As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied. PLGA-PTX with 7% (w/w) drug loading were incorporated into gelatin matrix. The pharmacokinetics were studied i...