Introduction poly(l-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic-organic composite has a great application prospect in bone tissue engineering. Many inorganic-organi...

Poly-L-lactic acid (PLLA) electrospun nanofiber scaffold is one of the most commonly used synthetic polymer scaffolds for bone tissue engineering application. However, PLLA is hydrophobic in nature, hence does not maintain proper cell adhesion and tissue formation, moreover, it cannot provide the osteo-inductive environment due to inappropriate surface characteristic and the lack of surface mot...

Background: Polyesters have been attractive for development of drug delivery applications because of their biocompatible, biodegradable and non-toxic properties. The objective of work is a comparative study on the release characteristics of two drugs loaded poly (L-lactide) (PLLA) film. Progesterone (Pro) and lidocaine hydrochloride (LidH) were chosen as the hydrophobic and hydrophilic model dr...

Modulating physical cell culture environments via nanoscale substrate topographic modification has recently been of significant interest in regenerative medicine. Many studies have utilized a polymer-demixing technique to produce nanotextured films and showed that cellular adhesion, proliferation, and differentiation could be regulated by the shape and scale of the polymer-demixed nanotopograph...

Poly(l-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and eliminat...

A novel biodegradable diblock copolymer, poly(L-cysteine)-b-poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of -benzyloxycarbonyl-L-cysteine (ZLC-NCA) with amino-terminated poly(L-lactide) (NH2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by 1H NMR, Fourier transform infrared (F...

Medical-profession-accepted and the US Food and Drug Administration (FDA)-approved biodegradable polymers have been used for tissue engineering applications over the last two decades due to their good biocompatibility and acceptable biodegradation properties. Poly(L-lactide) (PLLA) is a linear aliphatic biodegradable polymer and has been widely studied for use as a scaffolding material for huma...

We observe large-scale structures in hydrogels of poly(l-lactide)-poly(ethylene oxide)-poly(l-lactide) (PLLA-PEO-PLLA) ranging in size from a few hundred nanometers to several micrometers. These structures are apparent through both ultra-small angle scattering (USAS) techniques and confocal microscopy. The hydrogels showed power law scattering in the USAS regime, which is indicative of scatteri...

A novel procedure for biopolymer surface nanostructuring with defined surface roughness and pattern dimension is presented. The surface properties of sputtered platinum layers on the biocompatible polymer poly(l-lactic acid) (PLLA) are presented. The influence of thermal treatment on surface morphology and electrical resistance and Pt distribution in ca. 100 nm of altered surface is described....