Objective of the present study was to develop and evaluate thermoreversible in situ gelling drug delivery system for periodontal anasthesia. This system improves patient compliance by giving anesthesia at a site without distress of needle insertion. Thermoreversible gels were prepared by combining different concentration of pluronics F127 and F68. Formulations were evaluated in terms of their v...

Nickel oxide (NiO) nanoflowers are synthesized via a one-pot method using an amphiphilic block copolymer in aqueous solution. Pluronics F-127 works as structure-directing agent the formation of NiO nanoflowers. The controlled hydrolysis precipitating slowly releases ammonia that can form Ni(OH)2, which is stabilized polymer calcination removes polymeric part nanocomposite and converts Ni(OH)2 i...

Small-angle scattering (SAS) has been widely applied to study the microstructure of colloidal systems. Although colloids cover a wide range of materials, in general they can simply be viewed as basic building particles arranging themselves, according to their interaction, in a continuous medium. In this study, three seemingly very different systems were investigated under various conditions. Th...

The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most solid tumors, MTX serves as not only a cytotoxic agent but also a homing ligand. Cellular uptak...

A single-step synthesis of gold nanoparticles with an average diameter of approximately 10 nm from hydrogen tetrachloroaureate(III) hydrate (HAuCl4.3H2O) has been achieved in air-saturated aqueous solutions that contain poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers but not any other reducing agent. These amphiphilic block copolymers act as both r...

The purpose of this study was to develop pluronic-based in situ gelling formulations of metronidazole (MTZ) for treatment of bacterial vaginosis, aimed at prolonging the residence time, controlling drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance. The in situ gel formulations were prepared using different concentrations of pluronic F-127 (PF-127) alone ...

The effect of protein binding on kidney function has been studied by investigating the renal accumulation and secretion of the hippurate analogue 2-methylbenzoylglycine in the isolated perfused rat kidney in the absence and presence of bovine serum albumin (BSA). Experiments were performed with either 2.5% pluronic or a combination of 2.2% pluronic and 2% BSA as oncotic agents; a wide concentra...