Microtubule poisons inhibit spindle function, leading to activation of spindle assembly checkpoint (SAC) and mitotic arrest. Cell death occurring in prolonged mitosis is the first target of microtubule poisons in cancer therapies. However, even in the presence of microtubule poisons, SAC and mitotic arrest are not permanent, and the surviving cells exit the mitosis without cytokinesis (mitotic ...

Many drugs have been used for therapeutic purposes in Ayurveda since the Vedic period, and they are either of plant (Sthavar Udbhava), animal (Jangam or metal, mineral (Khanija) origin. After period Acharya Nagarjuna, use metals, minerals, poisonous became prevalent. Agada Tantra is a branch that deals with treatment various poisons. Toxicology concerned identification management types poisons,...

We report for the first time the use of a selective small-molecule inhibitor of DNA repair to potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-PK) as a potential target for leukemia therapy. Topo II poisons form cleavable complexes that are processed to DNA double-strand breaks (DSBs). DNA-PK mediates nonhomologous end joining (NHEJ). Inhibition of th...

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