The purpose of this study was to examine the contribution of dietary polyamines toward preventing cardiovascular disease (CVD). Age-standardized mortality rates as well as other relevant information regarding individuals with CVD were gathered from the World Health Organization and the International Monetary Fund in 48 different European and other Western countries. Food supply data were collec...

Polyamines are plant growth regulators distributed among all plant species. The major polyamines are diamine putrescine, triamine spermidine and tetraamine spermine. Polyamines are involved in a number of growth and developmental processes, as well as in plant responses to a variety of unfavorable factors. Polyamines can stabilize cell constituents and protect macromolecules from free radicals ...

The total cellular mass of the small intestine is well controlled and can adapt, with hypo- or hyperplasia, to a wide variety of stimuli. Luminal nutrients, hormonal factors and pancreatic and biliary secretions have all been implicated in the regulation of intestinal mucosal growth. The polyamines (putrescine, spermidine and spermine) and the key enzyme controlling their synthesis (ornithine d...

The polyamines putrescine, spermidine and spermine are ubiquitously expressed cations that essential for normal cellular function. AMD1 is a key, rate limiting enzyme drives the conversion of putrescine to thus can change ratios three polyamines. polyamines, specifically spermine, show dramatic reduction in levels aged skin yet their role within not well understood. purpose this study was exami...

Red blood cell and plasma polyamines in umbilical and maternal blood at delivery were measured using high performance liquid chromatography. The concentration of each polyamine in red blood cells and plasma of umbilical blood was significantly higher than in maternal blood. Spermidine and spermine concentrations in fetal red blood cells decreased markedly with the progress of pregnancy. In addi...

Abstract—As the population ages, age-related cognitive impairments are becoming an increasingly pressing problem. Currently, role of polyamines (putrescine, spermidine, and spermine) in pathogenesis various origin is actively discussed. It was shown that content brain tissue decreases with age. Exogenous administration makes it possible to avoid impairment and/or influence pathogenetic processe...

The polyamines are aliphatic cations which are present in millimolar concentrations in all mammalian cells, and are required for optimal growth of almost all cell types. In this study, the roles of polyamines in DNA replication in vitro and the mechanism by which polyamines affected DNA replication were examined using simian virus 40 DNA replication system in vitro. We found that polyamines inh...

Polyamines are known to increase in plant cells in response to a variety of stress conditions. However, the physiological roles of elevated polyamines are not understood well. Here we investigated the effects of polyamines on ion channel activities by applying patch-clamp techniques to protoplasts derived from barley (Hordeum vulgare) seedling root cells. Extracellular application of polyamines...

Transformed baby-hamster-kidney cells contain higher intracellular concentrations of polyamines than do normal cells. The difference is greater in high-density confluent cultures. Transformed cells incorporate exogenous putrescine into the cells at a faster rate than do normal cells. They also show a marked increase in the rate of spermine biosynthesis compared with normal cells. Transformed ce...