Melt pelletization experiments with sodium valproate as a hygroscopic drug were performed in a laboratory scale high shear mixer. In the current part, the effect of altering the binder liquid properties (using different binders, varying the temperature, or adding highly dispersed silicon dioxide to the molten binder) on the pellet size, size distribution and the growth rate was studied. Three m...

BACKGROUND AND PURPOSE The purpose of this study was to determine the distribution of polyethylene glycol-conjugated superoxide dismutase in the brain, cerebrospinal fluid, and various organs. METHODS Distribution of iodine-125-labeled polyethylene glycol-conjugated superoxide dismutase was determined in three groups of male Sprague-Dawley rats: a normotensive sham control group (n = 9) and g...

background: there are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. there are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...

Sena-Graph syrup has recently been formulated by an Iranian pharmaceutical company for being used in bowel evacuation before radiography, colonoscopy and surgery. This study compares the efficacy, adverse effects and patient compliance of two bowel preparation regimens with castor oil and Sena-Graph syrup in of outpatients for Intravenous Urography (IVU). One hundred and fourteen consecutive ou...

This study was undertaken to evaluate the antidiarrhoeal activity of 3, 7, 4'-trihydroxy-3'-(8″-acetoxy-7″-methyloctyl)-5, 6-dimethoxyflavone, a flavonoid isolated from the stem bark of Stereospermum kunthianum. The antidiarrhoeal activity was evaluated using rodent models with diarrhoea. The normal intestinal transit, castor oil-induced intestinal transit and castor oil-induced diarrhoea tests...

objectives: mentha longifolia l. (lamiaceae) is an annual herb that is used in the iranian traditional medicine for treating stomach and intestinal disorders. the purpose of this study was to determine the protective effect of m. longifolia on experimental diarrhea in a rat model. materials and methods: the antidiarrheal activity of essential oil of m. longifolia (20-80 mg/kg) was investigated ...

The crude oil of Malaysian castor bean ricinus communis L. seed was extracted by Soxhlet method using hexane. The physicochemical characteristics of castor bean oil were evaluated. The results showed that Malaysian castor seeds contain a relatively high percentage of total lipids content; 43.3% (per dry weight), high iodine value (84.5 mg/g) and saponification value (182.96 mg/g). The seed oil ...

Background: In this research, the decomposition of Aroclor 1254, including 20 kinds of poly chlorinated biphenyls (PCBs), in real waste transformer oil in the presence of PEG1000, NaOH, zero valent iron and H2O by microwave (MW) irradiation was studied. Methods: Central composites design (CCD) method was carried out for experimental design. The effects of microwave power levels (200- 1000 W), ...

Polyurethane nanoparticles (NPs) are promising candidates for the controlled and targeted delivery of therapeutics in a variety of biomedical applications. In this work, a report is made of NPs produced by miniemulsion polymerization with isophorone diisocyanate (IPDI) and castor oil, glycerol, and poly(ethylene glycol) (PEG) with molar masses 400 and 1000 as monomers and Tween 80, Span 80 and ...

emptied and washed, and the 24h efflux of inulin was determined; it is plotted against the final swelling ratio from the experiment in which the sac was stretched. An unstretched control is also included. In a similar unstretched sac, the half-time of raffinose escape was I4Omin. Clearly inulin escapes faster than the polyethylene glycol of comparable molecular weight at all porosities, but at ...