"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) o...

We developed a novel taxane-binding peptide (TBP) modified, biodegradable polymeric micelle that overcomes limitations of drug loading and poor serum stability typically seen with particle delivery, leading to enhanced pharmacokinetics and tumor distribution of docetaxel (DTX). The use of the taxane-binding peptide to increase docetaxel loading is particularly compelling as it takes advantage o...

This article proposes a method for obtaining stable hydrophobic inhibitor dispersions, where the micelle core contains solvent, corrosion and an organosilane. Such compositions can be used as polymer-type inhibitors low-carbon steel. Using electrochemical methods, tests X-ray photoelectron spectroscopy, features of formation polymeric layers organosilicon dispersions were studied.

Polymeric micelles are nanoscale core-shell structures formed by amphiphilic (block or graft) copolymers, that can self-aggregate in an aqueous medium. PMs characterized small size, spherical shape, lower critical micellar concentration, which gave higher
 stability for over conventional surfactant micelles. The core/shell structure permits polymeric micelle to entrap poor soluble drugs an...

Theoretical background for SAXS analysis In view of our TEM observations (Figure 2) and previously reported SAXS data obtained for a PLMA16PBzMA37 solution in n-dodecane1, it was assumed that the SAXS patterns corresponded to (i) a pure worm phase (Figure 4a) for the dilute PLMA16-PBzMA37 dispersion and (ii) spherical aqueous droplets stabilised by a layer of adsorbed worms for the concentrated...

Colloidal delivery systems including polymeric selfaggregates have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. Various characteristics of self-aggregates prepared from deoxycholic acid-modified chitosan were investigated by fluorescence spectroscopic and dynamic light scattering methods, and found to be contro...

Polymeric micelles, which form upon self-assembly of amphiphilic macromolecules, can act as vehicles for the oral delivery of these drugs. This manuscript.This review summarizes recent developments related to targeted anticancer drug delivery to tumor sites using polymeric micelles via active and passive.approach in the field of polymeric drug delivery systems was introduced by the. Functionali...

Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation tim...

A new experimental method for in vitro release studies of poorly soluble drugs from polymeric micelle systems was developed using a hydrotropic agent, sodium salicylate. It is difficult to maintain a good sink condition for poorly water-soluble drugs, such as paclitaxel (PTX), because of their low aqueous solubility. In this study, a good sink condition for PTX was achieved by using aqueous sod...

As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles as drug carriers for cancer therapy resides in their potential ability to preferentially elevate drug exposure in the tumor and achieve enhanc...