Polymeric microparticles with covalently attached biotin are proposed as versatile targeting vehicles for drug delivery. The proposed microparticles made of 85/15 poly (lactic-co-glycolic acid) (PLGA) will have biotin available on the outside of the particle for the further attachment with an avidin group. Taking advantage of biotin's high affinity for avidin, and avidin's well-known chemistry,...

The application of the microencapsulation technique in medicine and pharmacy has been extensively studied in recent years. The microencapsulation of small particles in polymeric, waxy or other kind of protective shells has become a well-established technology for coating and isolating various substances. The present paper presents the results obtained in a study concerning the influence of cros...

Polymeric microparticles have been used widely for sustained drug delivery. Current methods of microparticle production can be improved by making homogeneous particles in size and shape, increasing the drug loading, and controlling the initial burst release. In the current study, the hydrogel template method was used to produce homogeneous poly(lactide-co-glycolide) (PLGA) microparticles and to...

Poor oral bioavailability limits the use of curcumin and other dietary polyphenols in the prevention and treatment of cancer. Minimally invasive strategies that can provide effective and sustained tissue concentrations of these agents will be highly valuable tools in the fight against cancer. The objective of this study was to investigate the use of an injectable sustained release microparticle...

The use of superhydrophobic surfaces to produce polymeric particles proves to be biologically friendly since it entails the pipetting and subsequent cross-linking of polymeric solutions under mild experimental conditions. Moreover, it renders encapsulation efficiencies of ∼100%. However, the obtained particles are 1 to 2 mm in size, hindering to a large extent their application in clinical tria...

Introduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk human infection. Prolonged dosage forms ivermectin are effective against them. The first step creation such a was preparation study polymeric microparticles polycaprolactone with encapsulated ivermectin. Aim. Obtaini...

The facile surface functionalization of surfactant-free organic microparticles composed of polymeric 2,4,8,10-tetraoxa-3,9-diboraspiro[5.5]undecane allowed us to develop white-light emissive chemosensors for the real-time visual detection of Cu(2+) in HEPES buffer (pH 7.0) due to a synergistic response of fluorophores grafted onto the particles. A detection limit of 15.4 ppb for Cu(2+) in aqueo...