Background and Purpose Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability. We studied the influence of leukocytes on collagen-induced platelet aggregation in patients with acute ischemic stroke. Methods We investigated 23 patients within 2 days after stroke and...

OBJECTIVE Recent studies have assigned clinical significance and prognostic value to the detection of thyroglobulin (Tg) mRNA in the blood of patients subjected to total thyroidectomy for a papillary or follicular thyroid carcinoma. In this study, we investigated the diagnostic specificity of Tg mRNA detection, analysing blood samples from healthy volunteers and from patients previously subject...

In vertebrates, myeloid cells comprise polymorphonuclear and mononuclear lineages that arise from 2 successive waves of development: a transitory primitive wave giving rise to limited myeloid cells during embryonic stage and a definitive wave capable of producing myeloid cells throughout the fetal and adult life. One key unresolved question is what factors dictate polymorphonuclear versus monon...

Inhibitors of arachidonic acid oxygenation can inhibit polymorphonuclear leukocyte lysosomal enzyme release, aggregation, and generation of activated oxygen species, as stimulated by N-formylated chemotactic peptides. Guinea pig peritoneal leukocytes were prelabeled with [3H]arachidonic acid, and B-keto-prostaglandin F1,, thromboxane Bz, prostaglandin Ez, prostaglandin FZa, and 5-monohydroxyeic...

background: recognition of helminth-derived pathogen associated molecular patterns (pamps) by pattern recognition receptors (prrs), including toll like recep­tors (tlrs) is the first step towards initiating anti–helminth immune re­sponses. methods : using somatic antigens of ostertagia occidentalis, an important abomasal parasite of ruminants, the expression of ovine tlr2 and tlr4 in peripheral...

Abstract The concept of myeloid derived suppressive cells (MDSCs) has emerged in recent years as a group that pocess potent immunosuppressive activity. These expand under pathologic conditions and suppress the immune functions T cells, dendritic macrophages, natural killer cells. They have been shown to be involved pathological states cancer, autoimmune diseases, infections, such COVID-19. MDSC...

background: induced pluripotent stem cells (ipscs) can be obtained from autologous cells for therapeutic purposes. so, far, many studies have been done to produce induced pluripotent cells by transferring specific pluripotency genes using different methods. in this study, pluripotency gene expression induced by external stresses was assessed in cord blood mononuclear cells. methods: in this exp...

atherosclerosis is a chronic inflammatory condition that affects the arterial wall. oxidized low- density lipoprotein (ox-ldl) seems to have an important role in atherosclerotic plaque formation. this study was performed to investigate the effects of ox-ldl as well as pha on proliferation and gene expression of  peripheral blood  mononuclear  cells (pbmcs) in patients with atherosclerosis compa...

This report describes a system in which antibiotics could be compared for binding to different mammalian cells. These included functional phagocytes (human polymorphonuclear neutrophils; PMNs), non-phagocytic lymphocytes (mouse thymocytes), and non-functional leukocytes (mouse leukemia L1210 cells). When antibiotics bound to PMNs, they bound about the same to L1210 cells but much less to thymoc...