A multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. For this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 M HCl containing NaCl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...

Liquid protein formulations are prone to form aggregates. The effect of nonionic surfactants such as Polysorbate 20 (PS 20) and n-Dodecyl β-D-maltoside (DDM) on the prevention of aggregation and conformational changes of recombinant human IFNβ-1b (rhIFN β_1b) was explored. Polysorbate has been used in formulations of protein pharmaceuticals. There have been concerns about using PS 20 due to its...

Liquid protein formulations are prone to form aggregates. The effect of nonionic surfactants such as Polysorbate 20 (PS 20) and n-Dodecyl β-D-maltoside (DDM) on the prevention of aggregation and conformational changes of recombinant human IFNβ-1b (rhIFN β_1b) was explored. Polysorbate has been used in formulations of protein pharmaceuticals. There have been concerns about using PS 20 due to its...

Introduction Interferon beta-1b (IFNβ1b) is a form of interferon beta which has shown biological activity in a variety of in vitro and in vivo systems. Interferon beta belongs to a class of proteins known as interferons (IFNs). Interferons were originally classified based on the cell type from which they were derived [1]. The non-glycosylated IFNβ1b (Betaseron®) was the first IFNβ product appro...

This study describes a simple method for the selective and sensitive detection of cyanide and endogenous biological cyanide using polysorbate 40-stabilized gold nanoparticles.

BBB blood-brain barrier BMEC brain microvascular (capillary) endothelial cells CBSA cationic bovine serum albumin CdTe cadmium tellurium CTAB trimethylammonium bromide DRG dorsal root ganglia HSA human serum albumin ip intraperitoneal iv intravenous MWCNT multi-walled carbon nanotube PAMAM poly(amidoamine) PBCA polybutylcyanoacrylate PEG polyethylene glycol PLA poly(lactide) PLGA poly(lactic-co...

Effect of Polysorbate-80 on Oritavancin Binding to Plastic Surfaces – 1 Implications for Susceptibility Testing 2 3 4 Running Title: Polysorbate-80 effect on oritavancin binding 5 6 7 Francis F. Arhin 1 , Ingrid Sarmiento 1 , Adam Belley 1 , Geoffrey A. M c Kay 1 , Deborah C. Draghi 2 , 8 Parveen Grover 2 , Daniel F. Sahm 2 , Thomas R. Parr Jr. 1 and Gregory Moeck 1* 9 10 Targanta Therapeutics,...

Intravenous amiodarone (Amiodarone i.v.) is widely used to treat cardiac arrhythmias. The most frequent clinical adverse event associated with Amiodarone i.v. administration is systemic hypotension which has been attributed to the cosolvents used in the formulation, polysorbate 80 and benzyl alcohol. To minimize hypotension Amiodarone i.v. is diluted in 5% dextrose in water prior to administrat...

Polysorbate is widely used to maintain stability of biotherapeutic proteins in pharmaceutical formulation development. Degradation polysorbate can lead particle formation drug products, which a major quality concern and potential patient risk factor. Enzymatic activity from residual host cell enzymes such as lipases esterases plays role for degradation. Their high activity, often at very low co...