نتایج جستجو برای: pp1α
تعداد نتایج: 47 فیلتر نتایج به سال:
The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsyndromic hearing loss gene, taperin (C9orf75), encodes a protein that preferentially docks the alpha isoform of PP1. Taperin associates with PP1 through a cla...
UNLABELLED The NF-κB signaling network, which is an ancient signaling pathway, plays a pivotal role in innate immunity and constitutes a first line of defense against invading pathogens, including viruses. However, numerous viruses possess evolved strategies to antagonize the activation of the NF-κB signaling pathway. Our previous study demonstrated that the nonstructural protein 2C of enterovi...
Megakaryocyte development is particularly characterized by cellular enlargement and nuclear polyploidization, while erythroid development is characterized by cellular and nuclear atrophy, although both lineages originate from a common bipotential progenitor (MEP). The process of megakaryocyte enlargement and polyploidization, i.e., morphogenesis, is complex and controlled by tight regulation of...
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