نتایج جستجو برای: predictive biomarker
تعداد نتایج: 196512 فیلتر نتایج به سال:
Who do treatments work for and why? Understanding treatment-effect mechanisms in stratified medicine
The development of stratified medicine depends on an understanding of treatment-effect mechanisms (effects on therapeutic targets that mediate the effect of the treatment on clinical outcomes). Yet the evaluation of these mechanisms is often absent from the design and analysis of studies for stratified medicine, and even if present, is subject to unmeasured confounding. We review the problem of...
The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. Recently, there has been a push to incorporate group se...
There is a growing interest in the discovery of important predictors from many potential biomarkers for therapeutic use. In particular, a biomarker has predictive value for treatment if the treatment is only effective for patients whose biomarker values exceed a certain threshold. However, biomarker expressions are often subject to measurement errors, which may blur the biomarker's predictive c...
A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few studies used prediagnostic samples to assess the potential of the panels for early detection.We conducted amultisite systematic evaluation of biomarker panels using prediagnostic serum samples from the Prostate, Lung, Colorectal, andOvarian...
Head and neck squamous cell carcinomas have distinct mutation and copy-number profiles depending on human papillomavirus status. Although several challenges remain in biomarker implementation and clinical trial feasibility, incorporating available genomic data will expedite the development of novel therapeutics and predictive biomarker-driven clinical trials. See related article by Seiwert et a...
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