Concentration jump responses to 5-substituted (S)-willardiines were recorded from dorsal root ganglion (DRG) and hippocampal neurons under voltage clamp. After block of desensitization by concanavalin-A, dose-response analysis for activation of kainate-preferring receptors in DRG neurons gave the potency sequence trifluoromethyl > iodo > bromo approximately chloro > nitro approximately cyano > ...

In the primate visual system, area V4 is located in the ventral pathway and is traditionally thought to be involved in processing color and form information. However, little is known about its functional role in processing motion information. Using intrinsic signal optical imaging over large fields of view in V1, V2, and V4, we mapped the direction of motion responses in anesthetized macaques. ...

This report describes the fermentation, isolation, and structural elucidation of tetracenomycin (Tcm) F2 [2], a metabolite produced by a blocked mutant strain WMH1092 of the Tcm C [1] producer Streptomyces glaucescens and by the recombinant strain S. glaucescens WMH1077 (pWHM722). Elucidation of the Tcm F2 structure shows that 2 is the earliest intermediate identified to date in the biosynthesi...

Большинство христианских экзегетов I-V вв. в своих интерпретациях Книги пророка Ионы обращаются к теме противостояния Ниневии и Израиля, трактуя его таким образом, что ниневитяне являются прообразом язычников, поверивших Христа, то время как иудеи Его отвергли. В статье рассматривается вопрос, соотносят ли экзегеты это духовное противостояние с реальным, военным противостоянием ниневитян евреев...

Introduction. Here we derive mean field variational updates for MOMRESP. Although this derivation is largely a mechanical exercise, it is our belief that there is a contingent of crowdsourcing practitioners whose background is more practical than theoretical and who may appreciate seeing the mechanics of mean-field variational inference presented in a high level of detail for a model they are f...

There are many Qur’anic verses that talk about win in the doomsday and descried it as great, clear, great victory. The victory, according to exegetes: is everyone who escapes from a calamity, he has won, is, far what hated. victory mentioned Noble Qur’an eternal does not end, which Muslims attained through their strong belief God, obedience Him, doing God commanded them do life was pleased with...

OBJECTIVES To test Music Marker Theory (MMT) positing that early adolescents' preferences for nonmainstream types of popular music indicate concurrent and later minor delinquency. METHODS MMT was tested in a 4-year longitudinal study (n = 309). RESULTS The results showed that early fans of different types of rock (eg, rock, heavy metal, gothic, punk), African American music (rhythm and blue...

OBJECTIVES To assess the acceptability and quality of web-based videoconferencing telemedicine consultation platform in the treatment of opioid use disorder at TrueNorth Medical Centre. METHODS We conducted an interview based quality improvement initiative using an investigator-designed questionnaire. The questionnaire consisted of 17 Agree/Disagree questions, measured on a 7-point Likert sca...

The aim of the study was to investigate whether acamprosate, an agent attenuating relapse in human alcoholics, might modulate antioxidant status in rats chronically administered ethanol. Male Wistar rats were presented with a free choice paradigm between tap water and ethanol solution for three month to distinguish two groups of animals, preferring (PRF) and non-preferring (NPF) ethanol. Then, ...