Rats undergoing extinction of lever pressing after an external feedback for this behavior was attenuated by extinguishing its Pavlovian association with the reward (signal attenuation) exhibit compulsive lever pressing. The present study tested the effects of temporary inactivation of the orbital cortex in rats undergoing extinction of lever pressing that was or was not preceded by signal atten...

In the signal attenuation rat model of obsessive-compulsive disorder, 'compulsive' behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. In recent years several studies have reported that Lewis rats, an inbred strain derived from the Sprague Dawley strain, exhibit addictive and/or compulsive tendencies. The aim of the present study w...

Lymphatic vasculature is increasingly recognized as an important factor both in the regulation of normal tissue homeostasis and immune response and in many diseases, such as inflammation, cancer, obesity, and hypertension. In the last few years, in addition to the central role of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 signaling in lymphangiogenesis, significant new insights...

In order to conduct many desirable functions, service robots will need to actuate buttons and switches that are designed for humans. This paper presents the design of a robot named SwitchIt that is small, relatively inexpensive, easily mounted on a mobile robot, and actuates buttons reliably. Its operating characteristics were developed after conducting a systematic study of buttons and switche...

A simple and versatile method is developed for preparing anisotropic polymer particles by pressing polymer microspheres at elevated temperatures. Polystyrene (PS) microspheres are used to demonstrate this approach. Depending on the mechanical deformation and wetting of the polymers on the substrates, polymer structures with special shapes such as barrel-like or dumbbell-like shapes can be prepa...