Primary immunodeficiency disorders (PIDs) are a heterogeneous group of inherited disorders that affect different components of the immune system. There are more than 150 different disorders which have been described till date. Despite major advances in the molecular characterization of PIDs over the last 20 years, many patients remain undiagnosed or are diagnosed too late with severe consequenc...

Venous blood mononuclear cells from 42 children with primary immunodeficiency disorders and from controls matched for age were studied for lymphocyte subpopulations by E rosetting, surface immunoglobulin, and a panel of anti T cell monoclonal antibodies (OKT series). In 3 cases of severe combined immunodeficiency (SCID) due to adenosine deaminase deficiency, very few circulating T or B cells we...

The primary immunodeficiency diseases are a heterogeneous group of over 50 disorders which affect the cells, tissues and proteins of the immune system. These disorders were originally felt to be rare, to occur only in infants and young children and to be associated with severe clinical symptoms. However, as clinical experience with the primary immunodeficiency diseases has grown, it has become ...

objective: primary immunodeficiency diseases (pid) are rare and heterogeneous congenital diseases leading to increased unusual susceptibility to developing infections and causingsome malignancies and autoimmune diseases. this study was conducted to evaluate the epidemiological characteristics of primary these diseases in patients attending the clinic of immunodeficiency diseases in kerman.subje...

Primary immunodeficiency disorders (PIDs) are a genetically heterogeneous group of that affect distinct components the innate and adaptive immune system. To date, more than 300 different PIDs have been identified, most these manifesting by 1 year life. Recognition clinician is important because appropriate therapy will not only prevent death but also reduce long-term morbidity from recurrent in...

Common Variable Immunodeficiency (CVID) is one of the most common causes of Primary Immunodeficiency Disorders (PIDs) and of Primary Hypogammaglobulinemia in adulthood. Clinical features include variable combinations of infectious diseases, autoimmune diseases, lymphoproliferative disorders and gastrointestinal diseases. In this case report, delayed detection of the disease had a negative progn...

Primary immunodeficiency disorders are a heterogeneous group of genetic disorders, with different modes of inheritance, consisting of more than 100 different types. We constructed the DNA banking of primary immunodeficiency disorders for the first time in Iran. The DNA of 31 immunodeficient patients and their families (total of 92 samples) were collected, as the first step for construction of D...