PURPOSE To report a case of CD5+ primary intraocular B-cell lymphoma arising during methotrexate (MTX) and tumor necrosis factor (TNF) inhibitor treatment in a young patient with rheumatoid arthritis and uveitis. CASE PRESENTATION A 39-year-old woman treated with MTX and a TNF inhibitor for rheumatoid arthritis and uveitis had steroid-resistant vitreous opacity. A vitreous sample was obtained...

INTRODUCTION Cytofluorographic and molecular techniques are effective adjuncts in diagnosing intraocular lymphoma. Primary intraocular lymphoma is an uncommon entity predominantly of B cell origin and rarely with a T cell phenotype. The aim of the present paper is to report a case of a CD8-positive, TCR-alpha/beta-negative intraocular T cell lymphoma and review the literature. CASE PRESENTATI...

Non-Hodgkin lymphoma (NHL) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. We report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal NHL without central nervous system or systemic involvement. A ...

introduction: lymphoma may involve the gastrointestinal tract either primarily or as a manifestation of extensively disseminated systemic disease. stomach being the most frequent site of primary gastroin-testinal lyphoma, followed by the small bowel and colon respectively (1&2&3). for diagnosis of pi-mary small intestinal lymphoma (psil), one most satisfies the criteria specified by dawson and ...

REFERENCES 1. Tsukahara T, Takasawa A, Murata M, et al. NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax. Diagn Pathol 2012;7:114. 2. Rashidi A, Fisher SI. Primary adrenal lymphoma: a systematic review. Ann Hematol 2013;92:1583-93. 3. Kasaliwal R, Goroshi M, Khadilkar K, et al. Primary adrenal lymphoma: a single-center experience. Endocr Pract 2015;21:71924. 4. Santhos...

Despite recent advances in diagnosis and treatment, the prognosis of primary intraocular lymphoma (PIOL) remains poor, and the optimal treatment has yet to be defined. This review presents an overview of the current status of PIOL with a focus on recent advances in diagnosis and treatment. Recent studies show a decreasing time interval from symptom presentation to diagnosis, likely due to incre...

primary lymphomas of the lung are rare and usual radiographic findings are adenopathy, effusion, multiple lesions, solitary lesion or diffuse lesion. this paper presents a case of primary malignant tumor of the lung with a very rare radiological presentation. a 20-year-old male patient was admitted to our hospital due to fever, chills, productive cough and later development of hemoptysis. weigh...

PURPOSE Primary intraocular lymphoma is a high-grade non-Hodgkin lymphoma with a pathogenesis that is still unclear. Microenvironment is known to be crucial in controlling tumor growth and maintenance. To study the immune microenvironment in intraocular lymphomas and to characterize the cytokine polarization of infiltrating T-lymphocytes, a new murine model of intraocular B-cell lymphoma was de...