PURPOSE To evaluate the safety and efficacy of intravitreal ranibizumab for macular edema secondary to central retinal vein occlusion. METHODS Patients with macular edema secondary to perfused central retinal vein occlusion were enrolled in this ongoing, prospective, open-label study. Treatment was initiated with monthly intravitreal ranibizumab for 3 months. In the first year, additional inj...

BACKGROUND To investigate whether treatment as required 'pro re nata' (PRN) versus regular monthly treatment regimens lead to differences in outcomes in neovascular age-related macular degeneration (nAMD). Regular monthly administration of vascular endothelial growth factor (VEGF) inhibitors is an established gold standard treatment, but this approach is costly. Replacement of monthly by PRN tr...

INTRODUCTION Various factors play a role in the development of erectile dysfunction (ED). AIM To provide a descriptive comparison of erectile function response for tadalafil on-demand (PRN) and once-daily (OAD) dosing regimens in patients with common comorbid conditions, treatments, or risk factors that can be considered when treating ED. METHODS In total, 17 PRN and 4 OAD placebo-controlle...

PURPOSE To evaluate intravitreal aflibercept injections (IAI; also called VEGF Trap-Eye) for patients with macular edema secondary to central retinal vein occlusion (CRVO). DESIGN Randomized controlled trial. METHODS This multicenter study randomized 189 patients (1 eye/patient) with macular edema secondary to CRVO to receive 6 monthly injections of either 2 mg intravitreal aflibercept (IAI...

BACKGROUND Treat and extend (TE) treatment regimens have the potential to reduce the treatment burden placed upon patients receiving ranibizumab for neovascular age-related macular degeneration (nAMD). This study aimed to analyse changes in best corrected visual acuity (BCVA) and anatomical parameters in patients switching from a pro re nata (PRN) to a TE regimen during routine clinical practic...

Abstract Aim Post-operative pain was a recurrent issue reported at the dressing clinic following local anaesthetic (LA) hand surgery our regional centre. In absence of protocol, we aimed to standardise advice and analgesic prescriptions LA observe whether could be more optimally managed. Method cycle 1, day 1 7 scores were recorded for ∼30 patients using validated visual analogue scale (VAS). 2...

Recently, eight allelic variants of the pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States. It has been suggested that the divergence of the pertactin types of clinical isolates from those of the B. pertussis vaccine strains is a result of vaccine-driven evolution. Sequencing of the prn, which is relatively time-consuming, ha...

In order to enhance the positioning capability of terrestrial networks, a novel communication and navigation fusion signal is proposed. The novel signal multiplexes the communication and navigation signal in the same frequency band, and the navigation system is superimposed on the original communication system. However, the application of pseudorandom noise (PRN) sequences in the navigation sys...