Introduction: Ozone affects blood oxygen transport and the pro-oxidant-antioxidant balance. However, role of formed elements gas transmitters in these processes still remains unclear. The aim present study was to investigate effect ozone on balance a red cell suspension. Methods: suspension incubated with at concentration 6 mg/l substances affecting synthesis (nitroglycerin, sodium hydrosulfide...

ARDS is a disease process that is characterized by diffuse inflammation in the lung parenchyma. The involvement of inflammatory mediators in ARDS has been the subject of intense investigation, and oxidant-mediated tissue injury is likely to be important in the pathogenesis of ARDS. In response to various inflammatory stimuli, lung endothelial cells, alveolar cells, and airway epithelial cells, ...

In the vasculature, reactive oxygen species (ROS) generated by both mitochondrial respiration and enzymatic sources serve as integral components of cellular signaling and homeostatic mechanisms. Because ROS are highly reactive biomolecules, the cellular redox milieu is carefully maintained by small-molecule antioxidants and antioxidant enzymes to prevent the deleterious consequences of ROS exce...

Originally thought of as simply damaging or toxic "accidents" of in vivo chemistry, free radicals are becoming increasingly recognized as redox signaling molecules implicit in cellular homeostasis. Indeed, at the vascular level, it is plausible that oxidative stress plays a regulatory role in normal vascular function. Using electron paramagnetic resonance (EPR) spectroscopy, we sought to docume...

Once the cells are challenged by intraand extracellular environmental stimuli such as nitric oxide, calcium and pathogenic organisms, the oxidative balance between reactive oxygen species (ROS) (such as O 2 , H 2 O 2 , OH·) production and antioxidant defense systems (such as glutathione reductase and catalase) is broken, resulting in accumulation of ROS within cells. ROS is linked with various ...

The aim of the study was to investigate pro-oxidant-antioxidant balance in two series of examinations with two types of stressors (exogenous heat and the combined exogenous and endogenous heat) in trained and untrained men. The exogenous stressor was provided by Finnish sauna session, whereas the combined stressor was represented by the exercise in elevated ambient temperature. The men from the...

Gamma-glutamyltransferase (GGT) is a key enzyme involved in glutathione metabolism and whose expression is often significantly increased in human malignancies. In the past years, several studies focused on the possible role of GGT in tumor progression, invasion and drug resistance. The involvement of a pro-oxidant activity of GGT, besides its early recognized contributions to cellular antioxida...