Aim 3,4-methylenedioxymethamphetamine (MDMA) is one of the most widespread illegal drugs, used particularly by young people in the 15-34 age group. MicroRNAs (miRNAs) are endogenously synthesized, non-coding and small RNAs that post-transcriptionally regulate their target genes’ expression by inhibiting protein translation or degradation. miRNAs are increasingly implicated in drug-related...

BH3 profiling measures the propensity of transformed cells to undergo intrinsic apoptosis and is determined by exposing cells to BH3-mimicking peptides. We hypothesized that basal levels of prosurvival BCL-2 family proteins may modulate the predictive power of BH3 profiling and termed it mitochondrial profiling. We investigated the correlation between cell sensitivity to apoptogenic agents and ...

Introduction: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor found in adults. GBM has limited therapeutic options. Initial sampling establishes histopathologic diagnosis, identifies prognostic biomarkers, provides an opportunity for molecular profiling. By contrast, utility of repeat profiling recurrent not well established.

Like the private sector, the public sector makes more and more use of user profiling to personalize the electronic services that are being offered to citizens. User profiling offers great opportunities to make communication more effective and efficient, to infer and predict citizens’ behavior and to even influence behavior. However, some drawbacks must be considered. Important differences betwe...

Virtual execution environments, such as the Java Virtual Machine, promote platform-independent software development. However, when it comes to analyzing algorithm complexity and performance bottlenecks, available tools focus on platform-specific metrics, such as e.g. the CPU time consumption on a particular system. Other drawbacks of many prevailing profiling tools are high overhead, significan...

BACKGROUND Gene expression profiling test scores have primarily been used to identify heart transplant recipients who have a low probability of rejection at the time of surveillance testing. We hypothesized that the variability of gene expression profiling test scores within a patient may predict risk of future events of allograft dysfunction or death. METHOD Patients from the IMAGE study wit...

Prevailing profilers for Java, which rely on standard, native-code profiling interfaces, are not portable, give imprecise results due to serious measurement perturbation, and cause excessive overheads. In contrast, program transformations allow to generate reproducible profiles in a fully portable way with significantly less overhead. This paper presents a profiling framework that instruments J...

This paper presents an intrusion detection technique based on online sequential extreme learning machine. For performance evaluation, KDDCUP99 dataset is used. In this paper, we use three feature selection techniques – filtered subset evaluation, CFS subset evaluation and consistency subset evaluation to eliminate redundant features. Two network traffic profiling techniques are used. Alpha prof...

Silver nanoparticle therapeutics using symbiotic organisms can offer solutions to the current obstacles in antimicrobial therapies, because of cost-effective and eco-friendly properties over chemical and physical methods. In this study, we aim to synthesize silver nanoparticles using lichen (Parmotrema tinctorum) extract and evaluation of its antibacterial properties. Synthesized silve...