Objective: HNSCC is one of frequently cancers worldwide. all three categories: diagnostic, prognostic and therapeutic which are different from other departed biomarkers. These markers could serve as targets for new therapies, which would probably eventually change the outcome of HNSCC. The objective in this review was to highlight recent research about biomarkers that shows prognostic function ...

OBJECTIVE This study aimed to validate two prognostic biomarkers, pfetin and adenosine triphosphate-dependent RNA helicase DDX39 (DDX39), in gastrointestinal stromal tumour. Prognostic biomarkers have long been required for the optimal use of kinase inhibitors in gastrointestinal stromal tumour. METHODS The expression level of pfetin was immunohistochemically examined in 72 gastrointestinal s...

Objective Histopathological prognostication relies on pattern recognition, but as the number of biomarkers increases, human prognostic pattern recognition ability decreases. We have developed an automated quantitative method, hypothesized interaction distribution (HID) analysis, for identifying prognostic patterns of multiple biomarkers in situ. For follicular lymphoma (FL) we have previously d...

Despite the large amount of data in cancer biology and many studies into the likely survival of colorectal cancer (CRC) patients, knowledge regarding the issue of CRC prognostic biomarkers remains poor. The Tumor-Node-Metastasis (TNM) staging system continues to be the most powerful and reliable predictor of the clinical outcome of CRC patients. The exponential increase of knowledge in the fiel...

Background and Aim: Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all cancers worldwide, and if diagnosed early, it has a five-year survival rate of around 85%; however, a late diagnosis may decrease the survival rate to 50%. Aberrant expression of several genes is associated with the hallmarks of OSCC including uncontrolled cell proliferation, poor differentiation, invas...

Since the increasing update of the biomolecular scientific literature, biomarkers in stroke have reached an outstanding and remarkable revision in the very recent years. Besides the diagnostic and prognostic role of some inflammatory markers, many further molecules and biological factors have been added to the list, including tissue derived cytokines, growth factor-like molecules, hormones, and...

background : biomarkers accepted for clinical use in breast cancer have low sensitivity and specificity. thus, there is a need for new markers to assist in the diagnosis, prognosis and follow-up of breast cancer patients. this study aims to investigate the diagnostic, prognostic and follow-up role of serum bcl-2, bax and p53 proteins in breast cancer patients in comparison with those of serum c...

acute chest pain is an important and frequently occurring symptom in patients. chest pain is often a sign of ischemic heart disease. chest pain due to suspected acute coronary syndrome (acs) is responsible for a large and increasing number of hospital attendances and admissions. current practice for suspected acs involves troponin testing 10–12 hours after symptom onset to diagnose myocardial i...

Acute lymphoblastic leukemia (ALL) is a heterogeneous disease at the genetic level. Chromosomal abnormalities are used as diagnostic, prognostic and predictive biomarkers to provide subtype, outcome and drug response information. t(12;21)/ETV6-RUNX1 and high hyper-diploidy are good-risk prognostic biomarkers whereas KMT2A(MLL) translocations, t(17;19)/TCF3-HLF, haploidy or low hypodiploidy are ...