Promethazine is known to have protective activity in relation to CCl4-induced liver necrosis. This hepatoprotective property has been investigated with regard to the free radical scavenging and antioxidant properties of promethazine using isolated hepatocytes and microsomal suspensions. CCl4 is activated in both systems to free radical metabolites that bind covalently to lipid and protein, and ...

Background Laparoscopic gastric plication (LGP) is a technique in the restrictive category of bariatric procedures that reduces the gastric volume and increases intragastric pressure. Nausea and vomiting are the most common complications after this procedure. The goal of this research is to compare the combined effect of promethazine/dexamethasone versus Metoclopramide/ dexamethasone on the pre...

This study compares the efficacy of two drug regimens used for oral sedation in pediatric dental patients: chloral hydrate (50 mg/kg)/promethazine (1 mg/kg) and meperidine (1 mg/kg)/promethazine (1 mg/kg). Twenty-four pediatric dental patients, ASA Class I, were evaluated in this double-blind, randomized study. The patients ranged in age from 18 to 48 months. Each dental procedure under sedatio...

Carcinoid tumors with hepatic involvement can produce intense flushing, tachycardia, hypotension or hypertension and diarrhoea. Patients with limited cardiac reserve may not tolerate these effects under anaesthesia. Valvular heart disease associated with carcinoid tumors has been reported, but there is no record in the literature of such an association with coronary artery disease. This report ...

OBJECTIVE To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom. DESIGN Sequential randomised, double blind, placebo controlled trial. SETTING Public hospital in a venom research institute, São Paulo, Brazil. PARTICIPANTS 101 patients requiring antivenom treatment after being bitten by bothrops snakes. INTERVENTION Intramuscul...

Conscious Sedation is a technique in which the use of a drug produces a state of depression of central nervous system enabling treatment to be carried out, but during which verbal contact with the patients is maintained throughout the period of sedation. Various drugs have been used as sedative agents in pediatric dentistry to produce conscious sedation such a nitrous oxide, diazepam, midazolam...

The present study evaluated promethazine, an FDA-approved antihistamine, for treating the toxic effects of soman (GD). Male Sprague-Dawley rats, weighing 240-300 g, were pretreated 30 minutes prior to or treated 1 minute after GD administration (180 μg/kg, sc) with promethazine alone (40 mg/kg, ip) or in combination with oxime reactivator HI-6 (125 mg/kg, ip) and atropine methylnitrate (AMN; 2....