we find that that expression of claudin 5, a component of endothelial tight junctions, is dramatically down-regulated in Tal1-deficient embryos. Consistent with a defect in tight junction formation, localization of junctional components is disorganized in the Tal1-deficient endocardium. Therefore, we propose that Tal1 transcriptional targets regulate endocardial migration and tube extension thr...

The complement system is the central component of innate immunity and an important player in the adaptive immunity of vertebrates. We analyzed the expression patterns of several key members of the complement cascade during Xenopus development. We found extensive expression of these molecules already during gastrula/early neurula stage. Remarkably, several genes also showed an organ-specific exp...

Immunological and structural changes in the thymus and pronephros of Cyprinus carpio infected with the blood fluke, Sanguinicola inermis for 30 days, and exposed to 0.5 mg NH4+/1 for 48 and 168 h were investigated. Ultrastructural observations revealed cell disruption and highly vacuolated cytoplasm in the thymus. Of the cells that remained intact there was a significant increase in thrombocyte...