The transdermal drug delivery system is an alternative method of administration drugs. Most the drugs are delivered by conventional oral, topical, intravenous, and intramuscular methods limited efficiency. However, now clinical use because stratum cornea skin act as effective barrier that limits permeation through skin. To overcome this disadvantage, there Recent developments in delivery, such ...

Azidothymidine (AZT or ZVD), a Nucleoside Reverse Transcriptase Inhibitor (NRTI), is used as antiviral medication to treat Human Immunodeficiency Virus (HIV) which causes Acquired Immunodeficiency Syndrome (AIDS). It is the first approved anti HIV drug for AIDS used either in combination with other antiretroviral agents or as a single drug and is also included in WHO’s national list of essentia...

Drug delivery systems using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, there remain significant problems like instability in the general application of liposomes and niosomes for drug delivery. Proniosome have the potential to become a promising drug carrier in order to give stability to niosomal drug delivery ...

Objective: The main objective of the present study was to develop a controlled release formulation proniosomes thiocolchicoside. Methods: formulations were prepared with thiocolchicoside varying Span 60 and cholesterol ratio in range 4.5:1–1:4.5 using sucrose stearate as carrier by slurry method. different proniosomal characterized for micromeritic properties further %Entrapment efficiency, %Dr...

Colchicine is a secondary metabolite, originally extracted from plants of the genius colchicum it consists of the dried ripe seeds of Colchicum autumnale Linn., colchicine effectively functions as a mitotic poison or spindle inhibitor but the major disadvantage of the colchicine is toxicity and non target cell (normal cell)effect. That toxicity and targeted drug delivery can be controlled by ca...