The use of cationic polymers in gene therapy aims at improving the circulation, protection and delivery nucleic acids. modification poly(L-lysine) (PLL), including insertion hydrophobic moieties, is an efficient strategy to enhance transfection efficiency this synthetic system. PLL usually modified through either extremities polymer chains or amino groups present on side chains. Herein synthesi...

A series of phosphanes with imidazolyl substituents were prepared as hemilabile PN ligands. The corresponding gold(I) complexes were tested as bifunctional catalysts in the Markovnikov hydration of 1-octyne, as well as in the synthesis of propargylamines by the three component coupling reaction of piperidine, benzaldehyde, and phenylacetylene. While the activity in the hydration of 1-octyne was...

In the present research, an efficient process for the synthesis of propargylamine derivatives catalyzed by a novel nanocomposite of CuO/MnO2 is reported. CuO/MnO2 nano-catalyst was synthesized by the co-precipitation process and characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction(XRD), ICP-OES and BET surface area an...

Anthraquinones are of significant interest due to their biological activity, coloring properties, and synthetic applications. Here, we describe a mild convenient method for modification 1-ethynyl-4-hydroxyanthraquinone that was obtained from the Sonogashira cross-coupling reaction 1-hydroxy-4-iodoanthraquinone with alkynes. The copper(I) catalyzed one-pot three-component (A3-coupling) new secon...

Parkinson's disease (PD) is a progressive neurodegenerative, dopamine deficiency disorder. The main therapeutic strategies for PD treatment relies on dopamine precursors (levodopa), inhibition of dopamine metabolism (monoamine oxidase [MAO] B and catechol-O-methyl transferase inhibitors), and dopamine receptor agonists. Recently, a novel selective and irreversible MAO B propargylamine inhibitor...