We have recently developed analysis methods (GREML) to estimate the genetic variance of a complex trait/disease and the genetic correlation between two complex traits/diseases using genome-wide single nucleotide polymorphism (SNP) data in unrelated individuals. Here we use analytical derivations and simulations to quantify the sampling variance of the estimate of the proportion of phenotypic va...

The aims of the present study were to propose apolymerase chain reaction-restriction fragment length polymorphismPCR-RFLP genotyping method for the AY_376689:c.773C>T single nucleotide polymorphism SNP of the equine PRKAG3 gene, related to muscle performance, as well as to characterize this SNP and a second polymorphism, AAWR_02017454:g.121684T>C of the SPATA1 gene, related to male fertility, i...

Genetic improvement of livestock populations can be achieved through detection and mapping of genetic markers linked to quantitative trait loci (QTL). With the completion of the bovine genome sequence assembly, single nucleotide polymorphism (SNP) assays spanning the whole bovine genome and research work on large-scale identification, validation, and analysis of genotypic variation in cattle ha...

Leptin plays a key role in the regulation of the energy balance in mammals. Thus, the leptin and leptin receptor are being intensively studied in these animals. However, it remains unclear whether the leptin-mediated control mechanism is conserved in nonmammalian vertebrates such as the avian. In this study, the association of the SNP LEPR A286G with carcass traits was investigated in the EMBRA...

Association between Single Nucleotide Ppolymorphism (SNP) in the Intronic Region of (C2239T) B4-Defensin Gene with Milk Production Traits and Somatic Cell Count Holstein Cattle

The objective of this study was to evaluate the effect intronic single nucleotide polymorphisms (SNP) on temperament traits in a Brahman cattle population. SNP located CACNG4, EXOC4, NRXN3, and SLC9A4 candidate genes were genotyped 250 animals with records exit velocity, pen score, score. Rs3423464051:G>A CACNG4 gene associated velocity An silico analysis five showed that alternative alleles CA...

Associations between polymorphisms in candidate genes and economically important meat quality traits were assessed in a commercial population of Aberdeen Angus-cross animals. A number of traits were measured including 20 carcass and sirloin measurements recorded shortly after slaughter and also following maturation, 1 mechanical measure of tenderness and 7 taste panel assessed sensory traits. P...

The purpose of this study was: (i) to validate and detect copy number variations (CNV) in the cattle genome, and (ii) to find associations between CNV and feed efficiency traits. Average daily gain and dry matter intake were obtained from 3,884 beef cattle. Animals were genotyped with the panels of 50,000 single nucleotide polymorphisms (SNP) or 770,000 SNP. The log R ratio (LRR) was used as an...

To facilitate whole-genome association studies (WGAS), several high-density SNP genotyping arrays have been developed. Genetic coverage and statistical power are the primary benchmark metrics in evaluating the performance of SNP arrays. Ideally, such evaluations would be done on a SNP set and a cohort of individuals that are both independently sampled from the original SNPs and individuals used...