Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostaglandin dehydrogenase(s) derived from the kidney cortex were found to degrade all ...

inhibition of prostaglandin (pgs) production leads to decrease in orthodontic tooth movement (otm). it is not known whether inhibition of cyclooxygenase-1 (cox-1) or cyclooxygenase-2 (cox-2) is the key mechanism for this effect. in this study, the effect of celecoxib, a highly-selective cox-2 inhibitor, was investigated on otm in rats.four groups of male rats (seven animals in each goup) were u...

The role of prostaglandins in reproductive physiology is reviewed with particular emphasis on their possible importance in ovulation in humans. A possible interaction between gonadal steroids, biogenic amines and prostaglandins at hypothalamic-pituitary level, in relation to the release of luteinizing hormone releasing factor, and LH, is discussed. Anomalies regarding the role of oestrogens in ...

In the treatment of joint diseases, including osteoarthritis (OA), use standardized extracts undenatured type II collagen (UDC-II) is promising. It known that UDC-II involved in regulation innate and adaptive immunity (reduction autoimmune reactions stimulate cartilage degradation) reduction chronic inflammation activity (modulation cytokines prostaglandins). The effect on discoidin receptors c...

The responsiveness of the dentin-pulp complex is possible due to stimulation dental pulp cells, which begin synthesize and secrete dentin matrix. inflammatory process generated by harmful stimuli should be understood as a natural event immune response, resulting in recruitment hematopoietic cross endothelial barrier reach site affected injury order eliminate damage provide an appropriate enviro...

Prostaglandins are a group of chemical messengers that carry out a number of functions in the human body. One of their important functions is to enhance bone resorption. This may have a profound meaning for orthodontics, as the process of tooth movement is based on selective bone resorption and deposition around the teeth. This article reviews the literature concerning the discovery of prostagl...

Uterine leiomyomas are the commonest benign tumours in women, which estrogen-dependent and grow during reproductive life. Standard treatment for leiomyoma is hysterectomy or myomectomy according to women's age fertility. Prostaglandins particularly PGE1 as misoprostol have an impact on uterine contractions decrease blood loss.

Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of reproductive processes, including ovulation, implantation and menstruation. Prostaglandins have been ascertained to have a role in various pathological change...