Abstract Reconfiguration of protein conformation in a micro and nano particle (MNP) corona due to interaction is an often-overlooked aspect drug design nano-medicine. Mostly, MNP-Protein studies focus on the toxicity particles (NPs) biological environment analyze biocompatibility. However, preserving functional specificity proteins NP becomes critical for effective translation This paper invest...

background and objectives: hbha and mtb32c have been isolated from culture supernatants of mycobacterium tu- berculosis (m. tuberculosis) and mycobacterium bovis (m. bovis) and their immunogenicity previously studies have been confirmed. in this study, capability of constructed vector containing two mycobacterial immunodaminant antigens (mt- b32c-hbha), in producing new chimeric protein under t...

This scientific review deals with the mechanisms of action cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment DCP1-DCP2 decapping complex and disruption interaction mRNA ribosomes. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka databases. authors indicate that...

The human protein kinase ULK3 regulates the timing of membrane abscission, thus being involved in exosome budding and cytokinesis. Herein, we present first high-resolution structures domain. Its unique features are explored against background other ULK kinases. An inhibitor fingerprint indicates that is highly druggable capable adopting a wide range conformations. In accordance with this, descr...

acriflavine (3,6-diaminoacridine) is an anticeptic drug developed in 1912. previous research has focused on investigation of the intercalating features of acriflavine, but little is known about its interaction with proteins. drug-receptor interaction is of major interest in clinical science. the aim of the present study was to evaluate the ability of acriflavine to induce alterations in conform...

Nucleotide-binding leucine-rich repeat sequence (NBS-LRR) protein is the main immune receptor in plants and participates plant resistance to pathogens. When NBS-LRR activated by pathogen’s effector protein, its conformation changes from an inhibitory state state, then it activates downstream signal transduction initiates defense responses inhibit growth of The has major three domains: NBS, LRR ...

Background: The production of recombinant proteins in Escherichia coli is one of the most valuable achievements in biotechnology, with many therapeutic and diagnostic applications; however, the aggregation and misfolding of proteins that result in the formation of insoluble inclusion bodies is a disruptive factor in this process. Various solubilization and refolding methods can be used to impro...