We have developed a computer algorithm that can extract the pattern of conserved primary sequence elements common to all members of a homologous protein family. The method involves clustering the pairwise similarity scores among a set of related sequences to generate a binary dendrogram (tree). The tree is then reduced in a stepwise manner by progressively replacing the node connecting the two ...

With the remarkable increase in the number of DNA and proteins sequences, it is very important to study the performance of multiple pattern matching algorithms when querying sequence patterns in biological sequence databases. In this paper, we present a performance study of the running time of well known multiple pattern matching algorithms on widely used biological sequence databases containin...

objective(s): production of a recombinant and immunogenic antigen using dengue virus type-3 envelope protein is a key point in dengue vaccine development and diagnostic researches. the goals of this study were providing a recombinant protein from dengue virus type-3 envelope protein and evaluation of its immunogenicity in mice. materials and methods: multiple amino acid sequences of different i...

Brucella bacterium causes Brucellosis, an infectious disease spreading from animals to human. Brucella lumazine synthase (BLS) is a highly immunogenic protein with adjuvant properties, which has been introduced as an effective protein carrier for vaccine development. This protein also plays a significant role in inducing immune system. This study aimed to clone, express, and purify the BLS gene...

Let w ∈ 1{0, 1} * and let a w (n) be the number of occurrences of the word w in the binary expansion of n. Let {s(n)} n0 denote the Stern sequence, defined by s(0) = 0, s(1) = 1, and for n 1 s(2n) = s(n), and s(2n + 1) = s(n) + s(n + 1). In this note, we show that s(n) = a 1 (n) + w∈1{0,1} * s([w] 2)a w1 (n) where w denotes the complement of w (obtained by sending 0 → 1 and 1 → 0) and [w] 2 den...

So far, recombinant antigens of HIV-1, the etiologic cause of Acquired Immunodeficiency Syndrome (AIDS), have been widely used for the diagnosis and vaccine development. P17 or the matrix protein formed by the proteolytic cleavage of gag is strongly antigenic and is as conserved and immunogenic as p24. In some cases, antibodies to p17 are more prevalent than antibodies to p24 and the decline in...

1. Among the many different star-like motifs used in the geometrical art of Islam, there is one which stands out as distinctively "Islamic" (see fig. 1). We shall call this motif a geometric rosette, since it resembles a flower or rosette, with an outer ring formed by a variable number of "petals" encircling a central star. One possible interpretation of the formal, if not historical, origin of...