The hydration thermodynamics of the GXG tripeptide relative to the reference GGG is often used to define the conditional hydration contribution of X. This quantity or the hydration thermodynamics of a small molecule analog of the side-chain or some combination of such estimates, usually including factors to account for the solvent-exposure of the side-chain in the protein, have anchored the int...

The amount of water-accessible-surface-area, WASA, buried upon protein–protein association is a good measure the non-covalent complex stability in water; however, dependence binding Gibbs free energy change WASA proves to be not trivial. We assign precise physicochemical role thermodynamics and perform close scrutiny contributions favoring those contrasting association. analysis indicates that ...

Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute about a third of the proteins encoded in k...