The role of the kidney in the catabolism of Bence Jones proteins, intact IgG molecules, and isolated L chains, Fab and Fc fragments of IgG, was studied. The proteins were purified, radioiodinated, and their survival times measured in nephrectomized, ureter-severed, and control mice. Active endogenous catabolism was the major factor in overall Bence Jones metabolism since excretion as proteinuri...

Investigation of the serum proteins in disease is handicapped by lack of clinically applicable methods for resolving the complex system of proteins present in blood serum into homogeneous components. The only fractionation now possible is into groups of proteins having like solubility characteristics or electrophoretic mobilities or sedimentation constants (depending upon the method employed) b...

PURPOSE To report our experience in managing a case of bilateral optic disc oedema and unilateral cystoid macular oedema with a posterior subtenon (PST) injection of triamcinolone acetonide and intravitreal bevacizumab (IVB) in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. CASE REPORT A 50-year-old healthy woman complain...

Intestinal lymphangiectasia (IL) is a rare protein losing enteropathy caused by congenital malformation or obstruction of the intestinal lymphatic drainage system [1]. Elevated pressure in the intestinal lymphatic system causes dilatation and rupture of the lacteals, with loss of lymphatic fluid which is rich in fat and protein. Consequently the clinical features of diarrhea, growth retardation...

Tritium-labeled cholesterol has been fed to a selected series of patients to demonstrate a quantitative metabolic defect in lipid metabolism in the presence of abnormal serum lipoprotein spectra. Patients with abnormal serum lipoprotein spectra carry a greater fraction of their newly absorbed cholesterol in the esterified form than do normals. THE LIPOPROTEINS of human serum are conveniently de...

POEMS syndrome (also known as CroweFukase syndrome) is a serious systemic disease characterised by polyneuropathy, anasarca, skin lesions and associated with ostoclastic bone lesions and with M-proteinemia. The diagnosis of POEMS syndrome is made robust by finding increased serum/plasma vascular endothelial growth factor (VEGF) in addition to the combination of the above mentioned characteristi...

We report data from a prospective observational study performed in Martinique during a co-epidemic of dengue virus serotype 2 (DENV-2) and serotype 4 (DENV-4). Among 70 serum samples from patients with DENV-2 (n = 21) or DENV-4 (n = 49) infections, 47 (67.1%) were positive for dengue nonstructural protein 1 (NS1). Antigenemia correlated with plasma virus load and was independent of immune statu...

Exposure to toxic metals has become an increasingly recognized source of illness worldwide. Both cadmium and arsenic are ubiquitous in the environment, and exposure through food and water as well as occupational sources can contribute to a well-defined spectrum of disease. The symptom picture of arsenic toxicity is characterized by dermal lesions, anemia, and an increased risk for cardiovascula...