نتایج جستجو برای: proteome
تعداد نتایج: 17190 فیلتر نتایج به سال:
Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic gain of function (cytotoxicity associated with protein aggregates). Although potentially harmful, protein sequences predisposed to aggregation seem to be ubiquitous in all kingdoms of life, which suggests an evolutiona...
The object of this research was to report a draft proteome of human fallopian tube (hFT) comprises 5416 identified proteins, which could be considered as a physiological reference to complement Human Proteome Draft. The proteomic raw data and metadata were stored in an integrated proteome resources centre iProX (IPX00034300). This hFT proteome contains many hFT markers newly identified by mass ...
MOTIVATION The SWISS-PROT group at the EBI has developed the Proteome Analysis Database utilizing existing resources and providing comprehensive and integrated comparative analysis of the predicted protein coding sequences of the complete genomes of bacteria, archaea and eukaryotes. The Proteome Analysis Database is accompanied by a program that has been designed to carry out interactive InterP...
proteins are fundamental components of cells which mediate many essential biological processes. proteomics is a rapidly growing field for the study of proteome, the protein complement expressed by the genome of an organism or cell type. the large-scale analysis of proteins leads to a more comprehensive view of molecular and cellular pathways that improves the overall understanding of the comple...
MOTIVATION Liquid chromatography tandem mass spectrometry (LC-MS/MS) is the predominant method to comprehensively characterize complex protein mixtures such as samples from prefractionated or complete proteomes. In order to maximize proteome coverage for the studied sample, i.e. identify as many traceable proteins as possible, LC-MS/MS experiments are typically repeated extensively and the resu...
The availability of high-throughput genomic databases that establish protein dispensability, expression and interaction networks enables rigorous tests of competing models of protein evolution. Recent research utilizing these new data sets shows that protein evolution is more complex than was previously thought. Several variables, including protein dispensability, expression, functional density...
Proteomes are intricate. Typically, thousands of proteins interact through physical association and post-translational modifications (PTMs) to give rise to the emergent functions of cells. Understanding these functions requires one to study proteomes as "systems" rather than collections of individual protein molecules. The abstraction of the interacting proteome to "protein networks" has recent...
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