AIMS To do a genome-wide gene expression study of active and inactive ulcerative colitis and Crohn's disease (inflammatory bowel disease--IBD) and examine the most differentially expressed genes. As the study showed an extreme upregulation of all regenerating islet-derived genes (REG proteins) in active IBD, we further studied the expression of REGs on protein level in active and inactive IBD, ...

Twenty-eight patients with histologically proved pseudomembranous colitis have been seen in one hospital since July 1975. All patients with the disease had received antibiotics, six for infections not requiring operations; the other 22 cases all occurred after major surgery. All the patients had diarrhoea; six patients also had fever with clinical signs of sepsis, and three had abdominal pain t...

Draw the attention of clinical therapists, gastroenterologists, surgeons, general practitioners to problem antibiotic-associated diarrhea caused by irrational use antibacterial drugs. To highlight difficulties in diagnosing and managing patients with pseudomembranous colitis.

A 44-year-old Korean male died of rapidly progressive respiratory failure and refractory hypoxemia in 8 days after being admitted with a fever and dyspnea. The patient was diagnosed with pseudomembranous necrotizing tracheobronchial aspergillosis by fibroptic bronchoscopy and it was not related to an invasion of the pulmonary parenchyma. To the best of our knowledge, this case represents a pati...

Vancomycin and cholestyramine have been utilized both alone and in combination for the treatment of antibiotic-associated pseudomembranous colitis. Previous work for the treatment of antibiotic-associated pseudomembranous colitis. Previous work has demonstrated significant binding of vancomycin by the anion-exchange resin. The antibacterial activity of vancomycin was markedly reduced when the s...

Goldstein HH. Allergy and diabetes. In: Joslin's diabetes mellitus. 11th edn. Philadelphia: Lea and Febiger, 1971. 2 Leslie D. Generalised allergic reaction to monocomponent insulin. Br MedJ 1977;ii :736-7. 3 Sewell H, Smith DI, Willox A, Barnes CA, Matthews JB. Demonstration of islet cell antibodies. Lancet 1980;i :102-3. 4 Davidson JA, Galloway JA, Peterson BH, et al. The use of purified insu...

Objectives: The oral mucosa is a susceptible component of our anatomy with explicit implications on our well being. Consequently an unfamiliar pattern of oral mucosa pathology will raise much concern. Confronting unrecognized lesions undoubtedly challenges our professional acumen and clinical expertise. In attempt to discern the gravity of an exceptional condition the caring dermatologist may c...