County, Denmark, blood samples were drawn in the fasting state at 8 a.m. for determination of serum levels of calcium, protein, cholesterol, and triglyceride. The serum calcium levels were corrected to a constant serum protein level.2 All determinations were made in duplicate, and the coefficients of variation (C.V.) of duplicate measurements and the mean values and standard deviations (S.D.) a...

To the Editors: Clozapine is a tricyclic dibenzodiazepine derivative, atypical antipsychotic which exhibits relatively potent antiserotonergic (5-HT2, 5-HT3), antialpha1 adrenergic, antihistaminic (H1), antimuscarinic activity, and induces preferential blockade of dopamine D1 and D4 receptors in vivo. 2–4 Various adverse gastrointestinal effects have been associated with its use including const...

A 67-year-old man with a history of low anterior resection and diverting loop transverse colostomy for rectal carcinoma developed fulminant pseudomembranous colitis after stoma closure. Oral administration of vancomycin at 0.5 g every 6 h and colonoscopy with intracolic vancomycin administration was unsuccessful, but continuation of intracolic vancomycin with postural change resulted in dramati...

AB. Antibiotic-associated pseudomembranous colitis due to should be used with caution in view of possible risk of toxin-producing clostridia. Where C. difficile infection persists despite conven-Walsh J. Clostridium difficile colitis associated with chronic renal tional treatment, there are limited data to identify the best treatment. Saccharomyces boulardii (yeast) is a difficile and the etiol...

Rectal biopsies from five patients with clindamycin-associated colitis were studied with the intention of identifying fibrin thrombi in capillaries. Capillary thrombosis was present in all five cases, three with pseudomembranous colitis and two with non-specific colitis. The significance of capillary thrombosis and its relationship to other ischaemic lesions of the gut are discussed.

Pseudomembranous colitis is frequently associated with antibiotics and more rarely with chemotherapeutic agents such as 5-fluorouracil. The objective of this study is to show that it is possible to confuse this infection with chemotherapy associated toxicity. We present a 54 year old woman who underwent surgery for colorectal cancer and in the first cycle of chemotherapy with 5-fluorouracil dev...