OBJECTIVE To test five hypotheses on Post-traumatic stress disorder (PTSD): 1) Is PTSD the most prevalent disorder after trauma? 2) Is the proximity to the disaster related to the risk of PTSD? 3) Is PTSD associated with child mourning or separation, previous stress, or familiarity for psychiatric disorders? 4) Does the exposition to trauma increase substance abuse or somatization? 5) Can episo...

In order to address the significant gap in available psychiatric rating scale instruments designed to assess juvenile-onset bipolar disorder symptoms, the Juvenile Bipolar Research Foundation (JBRF) has supported the development of an assessment instrument for this purpose. This scale, called the Child Bipolar Questionnaire (CBQ), is a 65-item behavioral assessment tool. Preliminary data indica...

One possible explanation for this result is the size of the standard deviations of the measurements, which might be related to the wide range of Expanded Disability Status Scale (EDSS) scores permitted for patient inclusion. We are aware that a smaller range of EDSS scores would have selected a more homogeneous sample of subjects and probably would have reduced the size of the standard deviatio...

OBJECTIVE To assess the prevalence of neurodevelopmental and psychiatric co-morbidities in children and adolescents diagnosed with attention-deficit hyperactivity disorder at a tertiary care child and adolescent psychiatry centre. METHODS A total of 63 children and adolescents who were diagnosed with attention-deficit hyperactivity disorder and fulfilled the inclusion criteria were comprehens...

OBJECTIVE To find the prevalence of psychiatric disorders among the opioids dependents and to assess the severity of their addiction profile. METHOD Sample comprised of fifty patients admitted in drug treatment and rehabilitation center at Psychiatry Department of Lady Reading Hospital, Peshawar, between March to August 1997. DSM-IV diagnostic criteria were applied to diagnose substance depen...

Methods 130 patients (17 with major depressive disorder (UP), 67 with major depressive episode in bipolar disorder type II (BP II), 46 with major depressive episode in bipolar disorder type I (BP I) and 50 with mixed state (MS) according to the DSM-IV criteria) were included in the study and treated with bilateral ECT, on a twice-a-week schedule. The patients were assessed before (baseline) and...

OBJECTIVE Patients suffering from psychosis are more likely than the general population to commit aggressive acts, but the therapeutics of aggressive behavior are still a matter of debate. METHODS This pilot randomized, open-label study compared the efficacy of quetiapine versus olanzapine in reducing impulsive and aggressive behaviors (primary endpoints) and psychotic symptoms (secondary end...

OBJECTIVE We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. METHODS We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and...